Percutaneous Cardiopulmonary Support For Massive Fat Pulmonary Embolism In Pig

Objective: To evaluate the effectiveness of percutaneous cardiopulmonary treatment for massive fat embolism and to explore the feasibility of the technology for clinical pulmonary fat embolism。Methods: Randomly assigned 12 piglets (weight between 32.85-46.35kg) into 2 groups: control group (II) and test group (I). After tracheal intubation under general anesthesia, the piglets were injected fetal dose of fat (12ml) intravenously. Both groups received supportive treatment such as large dose of steroids, fluids, anticoagulants and positive inotropic agents. But for the test group, percutaneous cardiopulmonary bypass was set up through the femoral vein. MAP ,CVP ,PETCO2 , SpO2 , PaCO2 ,lactic acid (LAC) and free fatty acid were monitored continuously and recorded in before and right after fat injection and then every hour for 10 hours. The total dosage of positive inotropic agents , the survival time and mortality rate were compared between the two groups.Results: The mortality of 5th hour,10th hour in the test group were much lower than in t -he control group. The average survival time after fetal dose of fat injection in the control g -roup was 184.17±54.807 min with all the monitored vital signs deteriorated dram -atically. While in the test group, the piglets survived more than 10 hours after the fetal fat injection. Moreover, the vital signs and the monitored data returned to or close to the base - line unde -r the percutaneous cardiopulmonary support.Conclusion: Percutaneous cardiopulmonary support can effectively provide oxygen supply sufficiently for the primary damaged right heart failure and severe acidosis caused by massive pulmonary fat embolism and then it can facilitate the further advanced life support and eventually reduce the mortality and morbidity.