Expressions And Relations Of Bax And VEGF In Endometrial Cancers

Endometrial carcinoma is the female reproductive organs of the three common malignant tumor,Serious threat to women's health,More women aged over 50 in the menopause period or after the period suffer from the disease. In the past few years ,the morbidity of endometrium cancer has obviously been tending higher. The rate is close to or even exceeds the rate of cervical carcinoma,and due to poor late curative effect, the 5-year survival rate is very low. At present, Endometrial cancer etiology and pathogenesis factor was not very clear, needs to be further study. With the deepening of the research work, more and more data shows apoptosis abnormal and most malignant tumor of the disease. In addition, eidence, tumor growth and diffusion transfer is closely related with the formation of blood vessels.Gene Bax accelerating withering and dying is a protein discovered by Oltrai in 1993 using the methods of immunization and precipitation with Bel-2 gene protein product Bcl-2 distinctive mono clone immunebody. Many factors induce tumor cells to wilt and die, in the meantime Bax expression rises, which shows that Bax high expression is closely related with tumor cells. Vessel Endothelium Growing Factors (VEGF) is a multifunctional vessel growing factor, which is a accelerating vessel growing cell, which has the most powerful function. It plays an important role in inducing the cellulation of tumor vessel and accelerating the growth, attack and metastasis of tumor.Purpose: This present experiment approaches the role and correlation of endometrial cancer by check -ing the expressions that Bax and VEGF show in the endometrium,judge its as endometrial cancer early diagnosis and prognosis index of value.Method: In the diagnosis of endometrial cancer resection specimen and GuaGong gia -nt-cell specimens intraoperative 52 cases for group,for cervical carcinoma in situ and uterine fibroids muck normal endometrium specimens seen in 20 patients (control group). Use the immune tissue chemical staining method to test the expressions of Bax and VEGF, analyse the relations between their expressions in the endometrium cancer and the patient's age, clinical period, differentiation degree and lymph metastasis and explore the endometrial cancer between the function. Analyse all the data using the statistical software 13.Result:1. The rate of the positive expression of protein Bax in the endometrium cancer and that in the normal endometrium are 19.23%(10/52)and 70.00%(14/20) respectively. It is obvious that the former is lower than the latter. (P<0.05). The rate of positive expression of protein Bax in the endometrium cancer in the group of people under the age of 50 and that in the group above the age of 50 are 23.33%(7/30) and 13.64%(3/22) respectively, between which there is no remarkable difference(P>0.05). In clinical analysis Periods I-II and III-IV the rates are 29.17%(7/24) and 10.71%(3/28) respectively, between which there is no remarkable difference. (P>0.05) In histology grades G1-G2 and G3 the rates are 40.00%(8/20) and 6.25%(2/32), between which there is a remarkable difference (P<0.05). In the lymph metastasis group and none-lymph metastasis group, the rates are 11.76%(4/34) and 33.33%(6/18), between which there is no remarkable difference (P>0.05).2.The rate of positive expression of protein VEGF in the endometrium cancer and that in the normal endometrium are 76.92%(40/52) and 15%(3/20). The former is obviously higher than the latter. (P<0.05).In the endometrium cancer, the rate of positive expression of protein VEGF, in the group of people under the age of 50 and that in the group of above the age of 50 are 70.00%(21/30) and 86.36%(19/22). There is no remarkable difference between the two (P>0.05). In clinical periods I-II and III-IV, the rates are 70.83%(17/24) and 82.14%(23/28). There is no remarkable difference between the two (P>0.05). In histology G1-G2 and histology G3, the rates are 55%(11/20) and 90.63%(29/32). There is a remarkable difference between the two (P<0.05). In the lymph metastasis group and non-lymph metastasis group, the rates are 94.12%(32/34) and 44.44%(8/18) respectively. There is no remarkable difference between the two (P<0.05).3. Endometrial carcinoma with VEGF in between Bax had no significant correlation expression(χ2=0.066, P>0.05)。Conclusion:1. The rate of positive expression of protein Bax in endometrium cancer is lower than in normal endometrium. The lack of Bax protein that may happen with endometrial cancer related. In histology G1-G2 and histology G3, the rates of protein positive expression are remarkable (P<0.05). Notice that the morbidity of endometriu -m cancer has something to do with tissue infiltration depth.4. The rate of positive expression VEGF in endometrium cancer is obviously higher than that in normal endometrium. Notice that VEGF over-expression may be one of the pathogenys of endometrium cancer. It can serves as the sign of molecular biology to determine endometrium cancer. In histology G1-G2 and histology G3, the rates of protein positive expression are remarkable (P<0.05). Notice that the morbidity of endometrium cancer has something to do with tissue infiltration depth. In the lymph metastasis group and non-lymph metastasis group, the rates of positive expression of protein VEGF are remarkably different (P<0.05). Notice: Protein VEGF may be the factor of predicting the post-prediction of endometrium cancer.