Assessment Of Efficicy Of Transarterial Chemoembolization By Gelfoam Particles Using DSCT Perfusion Imaging For Hepatocellular Carcinoma

Objective:To discuss the clinical value of dual-source CT perfusion imaging(CTPI) in estimating the therapeutic efficacy of transcatheter arterial chemoembolization (TACE) by gelatin sponge particles for hepatocellular carcinoma(HCC).Methods:Dual-source CTPI was performed in 20 patients with HCC 1-3 days before and 6-8 days after TACE by gelatin sponge particles.The original imaging data was reconstructed in workstation to get the Time-density curve(TDC) and the color perfusion images of Arterial liver perfusion (ALP),portal vein perfusion (PV P),hepatic perfusion index(HPI).hepatic blood flow(HBF) and hepatic blood volume (HBV), and the relevant perfusion parameters were measured on the color images.The parameters obtained before TACE were compared with that obtained after TACE, and the differences were statistically analyzed.Results:Before TACE.in all patients the ALP and HPI of HCC lesions were sig-nificantly higher than that measured in the surrounding liver tissues, and PVP were lower, and their difference were statistically significant(P<0.05); Six to eight days after TACE, the ALP and HPI of HCC lesions remained were significantly lower than that measured before TACE, and PVP were higher, and their difference were statistically significant(P<0.05); While every parameters were not significantly different bet ween the surrounding liver tissues before and after TACE (P>0.05).Conclusion:Dual-source CT perfusion imaging can directly and quantitatively reflect the hemodynamic situation of HCC lesions both before and after TACE by gelatin sponge particles, which is very helpful for estimating the therapeutic efficacy of TACE.