Modified Xuefuzhuyutang Clinical Treatment Of Vascular Dementia

Purpose:The subject of clinical effects to be adopted, evaluation of traditional Chinese medicine syndromes, blood rheology, coagulation, blood lipids, liver and kidney function, mini-mental state examination, clinical dementia rating scale, ADL scale, mental retardation scaleto observe changes in other indicators Modified Xuefuzhuyutang treatment of vascular dementia in clinical efficacy, and further explore the pathogenesis of vascular dementia and qi and blood circulation, nourishing Qi Prevention and Treatment of the initial vascular dementia mechanism of actionto improve the quality of life, improve the clinical efficacy and prevention of vascular dementia progress and to provide ideas of other complications occur.Method:Will meet the inclusion criteria 50 patients with vascular dementia were randomly divided into two groups (treatment group, control group), treatment group,25 patients in the control group,25 cases were compared. A randomized, controlled clinical positive drug parallel study design.The treatment group was treated with donepezil hydrochloride tablets (Aricept-Eisai China), each one (5mg), and plus or minus 1 per night Xuefuzhuyu decoction, take one dose a day, each time taking 200ml, twotimes, morning and evening to take; the control group taking the same tablets of donepezil hydrochloride (Aricept-Eisai China):Each one (5mg),1 night; more drugs and even served a statistical effect of 8 weeks. Two groups before treatment of sex, age, course, license type, underlying diseases, clinical and other basic data points were compared by statistical analysis no significant difference (P> 0.05), that the two groups were comparable. According to the clinical efficacy of treatment, evaluation of traditional Chinese medicine syndromes, blood rheology, coagulation, blood lipids, liver and kidney function, mini-mental state examination, clinical dementia rating scale, ADL scale, mental retardation, and other indicators ScaleThe changes were assessed for statistical analysis and evaluation of the effectiveness of drugs.Results:Overall efficacy comparison:the treatment group healed in 23 cases, the basic control in 5 cases, significant improvement in 10 cases, progress in 8 cases, unchanged in 2 cases, the total effective rate was 92%; the control group under control in 3 cases, significant improvement in 6 cases, improvement in 11 cases, unchanged in 5 cases, the total efficiency of 80%, by Ridit test, P<0.01, significant effect that the treatment group than the control group.2. TCM syndromes comparison:the treatment group of drugs on patients with vascular dementia syndromes improvement was statistically significant (P<0.05), but the effect of the contrast between the syndrome was not significant.3. The impact on intelligence:MMSE before and after treatment, the improvement was statistically significant (P<0.05); the treatment group relative to the control group after treatment, MMSE is still improved after treatment, there are also significant differences (P> 0.05). This conclusion illustrates the treatment group on improvement of vascular dementia compared with the control group Intelligent better results.4. The impact on daily living:ADL before and after treatment, the improvement was statistically significant (P<0.05); treatment group relative to the control group remained ADL improved after treatment, there are also significant differences (P> 0.05). This conclusion illustrates the treatment group on improvement of vascular dementia compared with the control group Intelligent better results.5. Coagulation, blood rheology, blood lipids compared:the treatment group after treatment than before treatment improved the three; treatment group after treatment compared with the control group improved more significantly, after treatment, there was a significant difference(P<0.05).6. Comparison of liver and kidney function:the two groups before and after treatment showed no significant changes in liver and renal function, no significant; treatment group than the control group did not change significantly after treatment, no significant difference.Conclusion:Studies have shown that Xuefuzhuyutang treatment of vascular dementia treatment method is qi and blood circulation, nourishing Qi, TCM can significantly improve, improve patients mental state and daily living skills and other indicators, and the clinical use of safe non-toxicside effects and should be introduced.