Study Of The Correlation Between Trimester Maternal Serum AFP Levels And Adverse Pregnancy Outcomes

Objective In order to provide a theoretical basis for clinical forecasting of adverse pregnancy outcomes, this study analyzes the relationship between trimester maternal serum alpha-fetoprotein (AFP) levels and pregnancy outcomes, and explores the correlation between second trimester maternal serum AFP and adverse pregnancy outcomes.Methods Pregnancy outcomes of 796 pregnant women were retrospectively analyzed. They were screened for Down syndrome and the serum AFP levels were recorded in second trimester and other serum markers were within the normal range and delivered in third trimester in Tangshan Maternal and Child Health Hospital from May to March 2~4 mL fasting venous blood of all pregnant women at 15 to 20 +6 weeks of pregnancy was drawd, the serum was immediately separated and detected by chemiluminescent immunoassay. They were grouped into high serum AFP group (AFP≥2.OMoM, 118 cases included), low serum AFP group (AFP≤0.5MoM, 141 cases included) and the control group (AFP0.51 ~l.99MoM, 537 cases included). Pregnancy outcomes of each group were counted. The differences of adverse pregnancy outcomes incidences among each group and correlation between maternal serum AFP level of mid-pregnancy.Adverse pregnancy outcomes were analyzed using Chi-square test and spearman correlation test, and the predicted sensitivity and specificity of adverse pregnancy outcomes were calculated.Results1. Among the incidences of the adverse pregnancy outcomes, premature birth, premature rupture of fetal membranes,placental abnormalities, low birth weight children and pre-eclampsia were the top five.2. The incidences of premature delivery, premature rupture of fetal membranes, placental abnormalities, low birth weight children, preeclampsia in high levels of maternal serum AFP group were significantly different when compared to the control group (P <0.05), and the sensitivity were 66.67%, 58.82%, 63.63%, 70.00%, 75.00% respectively, and the specificity always 92.84%.3. Over-top second trimester maternal serum AFP level positively correlated with the incidences of preterm, premature rupture of fetal membranes, placental abnormalities, low birth weight children and severe pre-eclampsia (r were 0.277,0.190,0.150,0.64,0.162, each P<0.05);Low levels of maternal serum AFP in mid-term pregnancy didn't correlate with the incidences, premature rupture of fetal membranes, placental abnormalities, low birth weight children,and severe pre-eclampsia (r were 0.019,0.002,0.001,0.001 , 0.005, each P > 0.05).Conclusions1.Over-top second trimester maternal serum AFP level positively correlated with the incidences of preterm, premature rupture of fetal membranes and severe pre-eclampsia.2.Low levels of maternal serum AFP in mid-term pregnancy didn't correlate with the incidences, premature rupture of fetal membranes, placental abnormalities, low birth weight severe pre-eclampsia.