Relevant Factor Analysis Of Liver Function Decompensation After Hepatectomy Or TACE To Large Hepatocarcinoma

Objective: To investigate the relevant factors of liver function decompensation after hepatectomy or TACE in the patient with large hepatocarcinoma. Research the assessment methods for the risk of treatments.Method: Retrospective study the clinical data of 60 patients with large hepatocarcinoma treated with hepatectomy (n=40) or TACE (n=20). The patients were grouped according to liver function compensation level after treatments; the differences between the groups were analyzed.Results: 1.To the patients with hepatectomy, between group A and B, the differences of tumor size(6.53±1.52cm vs 8.53±3.31cm), ICGR-15 value(5.82±4.29% vs 12.27±6.36%), time of operation(191.75±38.53min vs 262.05±58.54min), time of portal triad clamping(6.65±7.62min vs 13.30±9.47min) and blood loss(322.5±214.28ml vs 790±766.33ml) were statistical significance, P<0.05. A Logistic regression analysis showed ICGR-15 value is the independent risk factor for liver function decompensation after hepatectomy. The rate of liver function decompensation after hepatectomy in the patients with ICGR-15≤10% is lower than it in the patients with ICGR-15>10%(33.33% vs 84.62%,P<0.05). 2.To the patients with TACE, between group A(n=10) and B(n=10), the differences of ICGR-15 value(7.97±5.74% vs 19.81±12.83%)and ALB value before TACE(39.72±2.71g/L vs 33.91±3.21g/L ) were statistical significance, P<0.05.Conclusions: Size of tumor, ICGR-15 value, time of operation, time of portal triad clamping and blood loss were the main risk factors of liver function decompensation after hepatectomy; and ICGR-15 value was the independent risk factor. ICGR-15 and ALB value were the risk factors of liver function decompensation after TACE. ICGR-15 combined liver excision quantity or ALB value would be used to predict the risk of liver function decompensation after hepatectomy or TACE.