The Relationship Between The Plasma Level Of HSP70 And Coronary Heart Disease

Objective:To investigate the relationship between the plasma level of heat shock protein 70 (HSP70) and the development and severity of coronary heart disease(CHD)Method:①83 CHD patients and 83 number- ,years- and sex- matched controls who do not have coronary heart disease and the vital organs diseases were recruited in the case- control study.②The plasma level of HSP70 were measured using enzyme-linked immunosorbent assay(ELISA). Everybody's general index (including weight index, blood pressure, the situation of smoking and drinking, and the history of hypertension and diabetes) were record. The level of triglycerides was detected by clinical standard detectors.③The data of HSP70 level were analyzed by the statistical software SPSS13.0 to find the relationship between HSP70 and coronary heart disease.Results:①The plasma level of HSP70 in CHD patients was significantly higher than that in controls(P for trend<0.001).②Multiple Logistic regression analysis result indicated that the high level of HSP70 was the independent risk factor of CHD.③Increasing level of HSP70 was significantly associated with higher risk of CHD (P for trend <0.001).④Increasing level of HSP70 was not associated with significantly increasing severity of CHD as evaluated by number of diseased vessels detached by angiography.Conclusion:The plasma level of HSP70 is related to risk of CHD, but not to severity, suggesting that HSP70 may play important roles in the currency of CHD.