A Comparative Study On Sexual Hormone Levels In Bipolar Disorer Pathents With Different Episodes Their Relationship To Affective Symptoms

Objectives:To explore the sex hormone changes in patients with bipolar disorder and to testthe relationship between sex hormone and episodic features of the disorder.Methods:Experimental Group was composed by hospitalized patients with bipolar disorderin Guangzhou Psychiatric Hospital during the period between 2009 to 2010. Theymust satisified the followlling requirements, before they were enrolled into the study.(1)met the diagnostic criteria for bipolar disorder of CCMD-3; (2) aged between16-55 years; (3) no biological familial relationship between any patients ; (4) notaking antipsychotic drugs, mood stabilizer or other drugs which will effect endocrinein the past six months; (5) being divided into Depressive group(n=66) and Manicgroup (n=70).Matched Group: (1) healthy people matched with experimental group in age,gender and education; (2) no lifetime mental disorders, family history of any grossmental disorders and psychoactive substances dependence; (3) no blood relationshipamong group members; (4) no mood disorder (BRMS score is less than five and BDI score is less than four).The following samples were excluded from both experimental group andmatched group: (1) members with endocrine or immunological diseases; (2) pregnantwomen; (3) members who have personality disorder or mental retardation; (4)substance or alcoholic dependence.All subjects are from Chinese main ethnic group who are right handedness, andthey would take a venous blood examination to test sex hormone at 7 am in the nextday. The testing time of female subjects should be follicular phase (3-5 days aftermenstruation).Besides, both experimental and matched group should finished thequestionnaire (about name, age, gender, marriage, education, carrier, age fall sick,clinical case, family medical history, character trait before disease, menarche time,dysmenorrheal, menstrual disorder), BDI and BMRS evaluations.Results:Nonparametric Mann-Whitney U Test of sexual hormone levels between thepatients groups (i. e., manic group/ depressive group) and normal group shows that(1) the PRL , FSH,E2, LH and PRG of manic group are statistically significantlyhigher than normal group, but there is no statistical difference on T; (2) the PRL andPRG of depressive group is statistically significantly higher than normal group, butthere is no statistical difference on T, E2, FSH and LH ;(3) PRL, T, E2 and LH ofmale manic patients are significantly higher than normal people while there are nostatistical difference on FSH and PRG; the PRL and PRG of female manicpatients are statistically significantly higher than normal people while there are nostatistical difference on other variables; (4) the PRL, E2 and PRG of male depressedpatients are significantly higher than normal people while there are no statisticaldifference on T, LH and FSH; the PRL, PRG of female depressed patients arestatistically significantly higher than normal people while there are no statisticaldifference on other variables;(5) the E2 of manic group is statistically significanthigher than depressive group, and the T, E2 of male manic patients are higher thanmale depressed patients.Pearson relation analysis on sex hormone levels, BDI scores and BRMS scores shows that: (1) there is no significant relationship between sex hormone levels andBRMS scores; (2) FSH is positive correlated with BDI scores.Conclusion :(1) Patients with bipolar disorder maybe have HPG axis dysfunction.(2) Bipolar mania and bipolar depression are two subtypes of the same diseasespectrum. Manic patients have more changes in sex hormone levels.(3) T and LH are susceptible in bipolar manic men.(4) FSH value is positive correlated with BDI scores, which prompt that the levelof FSH is correlated with the severity of depression.