Changes Of The Levels Of Serum IL-2 And IL-10 And Their Significance In Neonates With Unconjugated Hyperbilirubinemia In Different Phototherapy Methods

Objective:To explore changes of the levels of serum IL-2 and IL-10 and their clinical significance in neonates with unconjugated hyperbilirubinemia in different phototherapy methods.Methods:Forty-eight full-term newborns with unconjugated hyperbilirubinemia were chosed as subject. They were randomly and equally divided into persistent phototherapy group and intermittent phototherapy group.Their serum bilirubin were detected before and after phototherapy,the levels of serum IL-2 and IL-10 were detected by the enzyme linked immunosorbent assay(ELISA).The results were analyzed by SPSS 13.0 for Windows software.Results:1.The two groups of serum bilirubin concentration were significantly decreased after phototherapy; At 24 hours after phototherapy the serum bilirubin concentration of persistent phototherapy group were significantly lower than that of intermittent phototherapy group (P<0.01); At 48 hours after phototherapy the serum bilirubin concentration were similar in the persistent phototherapy group and intermittent phototherapy group (P>0.05); 2.The two groups of serum IL-2 levels were both significantly increased after phototherapy; At 24 hours after phototherapy the serum IL-2 levels of persistent phototherapy group were significantly higher than that of intermittent phototherapy group (P<0.01); At 48 hours after phototherapy the serum IL-2 levels were similar in the persistent phototherapy group and intermittent phototherapy group(P>0.05);3.The levels of serum IL-10 were significantly increased in persistent phototherapy group after phototherapy, while the levels of serum IL-10 did not change obviously in intermittent phototherapy group; At 24 hours and 48 hours after phototherapy the serum IL-10 levels of the persistent phototherapy group were markedly higher than that of intermittent phototherapy group (P<0.01);4.The levels of serum IL-2 were sharply negative correlation with the serum bilirubin concentration.Conclusion:The therapeutic effect of persistent and intermittent phototherapy in treating neonatal hyperbilirubinemia were basic homology; and the levels of serum IL-2 were significantly increased in both phototherapy methods;but the levels of serum IL-10 were significantly increased in persistent phototherapy, while there were not changed obviously in intermittent phototherapy group. The results demonstrate that phototherapy could affect the function of the immune system in the neonates with unconjugated hyperbilirubinemia, which provide certain clinical evidence for neonatal with unconjugated hyperbilirubinemia at the choice of phototherapy methods and considering the use of immunity regulator in phototherapy,but how to regulate specifically immune funcion remains to be discussed futher.