Studies On Structural Modification Of Chlorogenic Acid

Chlorogenic acid found in many plants, with widespread pharmacological actives. In recent years, research on chlorogenic acid has developed rapidly. Current studies show that chlorogenic acid has a low oral absorption rate in vivo and exists in plasma mainly in the form of metabolites, it mainly excreted through the kidneys.Chlorogenic acid shows many functions such as antioxidant, antitumor, antibacterial, antiviral, immune adjustment, hypoglycemic, etc. This thesis reported the structure modification on chlorogenic acid in order to find structure with better pharmacological activities. The futher study on chlorogenic acid to provide theoretical basis about scientific pharmaceutical and rationally drug design for us.The paper reviews the structure of chlorogenic acid and its analogues in the research progress and pharmacological activity, as well as its structure unit qunny acid and caffeic acid are also discussed. In chapterâ…¡andâ…¢we expected to synthesis the Tamiflu analogues structure by modifying the chologenic acid. we tried to eliminate the hydroxyl of C1, hydrolysis esters base of C3, oxidate and aminate the hydroxyl of C4 and C5, qunny unit is also useful starting materials as chiral source for the syntheses. Chapterâ…£is about carboxyl functional groups modification, which is divided into two parts, including the carboxyl reduction and amidation reactions.The summary and prospect of our research work was described in chapterâ…¤and the spectrogram data and specific experiment process of the related compounds in this thesis were described in chapterâ…¥.The structures of compounds in this thesis were identified by NMR spectrogram.