Comparative Study Of Systolic And Diastolic Heart Failure And Myocardial Energy Expenditure, Plasma BNP, Hs-CRP

Objectives: To Comparative study of systolic and diastolic heart failure and Myocardial energy expenditure,plasma BNP,Hs-CRP,further explore MEE statusing of cardiac function.Methods: A total of 99 CHF patients were divided into 3 groups according to the systolic function (DHF n=38;SHF n=61) or the New York Heart Association(NYHAII,n=27;III-IV.n=72) criteria.30 normal cases acted as agematched control were included in this research. Routine examinations including serum Hs-CRP(ELISA) was made on the next moring after admission; and plasma BNP(chemiluminescence sandwich ELISA) was made immediatelly after admission;echocardiography was performed on the third day after admission. LVEF and MEE were measured or calculated.Results: Plasma BNP, Hs-CRP both increased in Heart failure(HF)(P <0.01), MEE was significantly higher in SHF patients than in controls(P<0.01)and similar between DHF patients and controls(P>0.05).MEE increased in proportion to decrease of LVEF and increase of NYHA grades in CHF patients(all P<0.05).Bivariate analysis confirmed that MEE Was significant correlated with Hs-CRP and BNP.Conclusions: MEE is an important biomarker of heart failure,and it is more sensitive in SHF than DHF.Hs-CRP and BNP can all reflect the degree of the heart failure.MEE derived from standard echocardiographic measurements is an effective indicator for myocardial bioenergeties and significantly.