Related Investigation Of The Serum Level Of EPCA,PSA In Patients Of Prostate Cancer

Objective:To evaluate the relationships between Gleason score,clinical stages and early prostate cancer antigen (EPCA),total PSA,free-to-total prostate specific antigen ratio (f/tPSA) in patients with prostate cancer.To discuss its value of diagnosisd and differential diagnosis in the clinical application.Methods:The levels of serum total PSA,free PSA were detected by TRFIA in 30 prostate cancer patients,45 benign prostatic hyperplasia(BPH) patients and 36 normal subjects.The method of ELISA was used to measure the serum concertration of EPCA in these people.Results:(1)Serum EPCA levels in the prostate cancer were significantly higher than that in BPH patients and normal subjects (P<0.05).(2)The serum levels of total PSA in prostate cancer and BPH group were significantly different from the normal group(P<0.05) while there were no differences between the prostate cancer and BPH group (P>0.05).(3)The f/tPSA ratio in the prostate cancer were significantly lower than that in BPH group and normal patitents(P<0.05) while there were no differences between the BPH group and normal group(P>0.05).(4)The area under ROC curve of three indexes in decending order was EPCA and f/tPSA ratio,tPSA.The specificity of EPCA were significantly higher than that of tPSA and f/tPSA under the same sensitivity. When the cutoff of EPCA and f/tPSA were 9.94 and 1.6,the sensitivity and specificity of diagnosing PCa were 90% and 97.5%,63.3% and 76.5% respectively.(5) In 30 cases of prostate cancer,total PSA was significantly positively correlated with Gleason score (r=0.475,P=0.000),and clinical stage (r=0.589,P=0.000).f/tPSA was significantly inversely correlated with Gleason score (r=-0.102,P=0.045),and clinical stage (r=-0.216,P=0.019).There was no statistically signicicant association of serum EPCA levels with Gleason score and clinical stage of prostate cancer (P>0.05).Conclusions:(1)Detection the serum levels of EPCA would be effective for the diagnosis and differential diagnosis of the prostate cancer.(2)Serum total PSA and f/tPSA are correlated with Gleason score and clincical stage which are predictors of prognosis in prostate cancer.