| Objective:To explore the exposure status and characters of the risk factors of ischemic stroke in Qingdao, provide the scientific evidence to the intervention planning and support the clinical prevention programs of ischemic stroke in Qingdao area. Also provide references to related fundamental and clinical researches.Methods:A retrospective case-control study was conducted. From September 2007 to September 2009, two hundred and sixty five ischemic stroke patients (40-70yr) who were confirmed and first admitted in Qingdao municipal hospital were randomly sampling as ischemic stroke group (case group); other 265 normal subjects (40-70yr) who accepted physical examination in physical examination center of Qingdao municipal hospital were randomly selected as control group.Investigate and record patients'age, sex and race as general informations, and hypertension, cardiopathy, diabetes, hyperlipidemia, hyperuricemia, overweight, smoke and drinking, total 8 reseach items. All the data were confirmed, inputed and statistically analyzed by SPSS 13.0. Pearson's chi-square test was used to assess comparison of numeration data. When 1≤T<5, an adjusted chi-square value is calculated. The measurement data were compared with independent-samples t test. The t'test was used for variance nonhomogeneity. Single factor analysis was used to analyze the effect of risk fators on ischemic stroke. Odds ratios and 95% confidence intervals were calculated. All the P values meant two-tailed probability. Significance level was 0.05.Results:The differences of age, sex and race between case group and control group are not statistically significant (P>0.05), therefore, the outcomes of case group are comparable to control group's. Exposure rate of hypertension in case group (61.89%) is higher than that of control group (53.21%). There's significant difference between the two groups (x2=4.086, P<0.05; OR= 1.428; 95%CI,1.011-2.017). Exposure rate of cardiopathy in case group (26.04%) is also higher than that of control group (4.53%). The difference is statistically significant (x2=47.347, P<0.01; OR=7.422; 95%CI,4.193-13.137). Exposure rates of diabetes in case group and control group are 32.45% and 8.68%, separately. The former is obviously higher than the later (x2=45.840, P＜0.01; OR=5.055; 95%CI,3.162-8.081). Exposure rates of hyperlipidemia in case group (47.92%) is apparently higher than that of control group (15.85%). The difference is significant (x2=62.765,P<0.01; OR=4.886; 95%CI, 3.300-7.234). The testing results of total cholesterol and triglyceride in case group are 5.04±1.42 mmol/L and 1.71±1.18 mmol/L, separately. They are higher than those of control group (3.69±1.04 mmol/L,1.30±0.97 mmol/L) (t=12.486 and 4.369, P＜0.01). Exposure rates of hyperuricemia (15.85%) and testing result of serum uric acid (384±92μmol/L) are also higher in case group. They are obviously higher than those of control group (5.66%,361±101μmol/L). The differences are significant (X2=14.331,t=2.741, P＜0.01; OR=3.139; 95%CI,1.736-5.676). Overweight and fatness ratio of case group (71.70%) is higher than that of control group (63.02%). Among these, the fatness ratio of case group reaches 36.23%. It's obviously higher than the control group's (19.25%). There is significant difference between two groups (X2=19.138, P<0.01; OR=1.487; 95%CI,1.245-1.776). Exposure rate of smoke of case group is about 61.13%. It is obviously higher than control groups's 32.45% (X2=43.773, P<0.01; OR=3.274; 95%CI,2.304-4.652). Smokers of case group smoked heavier (heavy smoke,53.70%; middle,38.89%) than those of control group (heavy,47.68%; middle,30.23%). Drinking ratio of case group (35.47%) is higher than control group's (23.40%). There's significant difference between two groups (X2=9.302, P<0.01; OR=1.800; 95%CI,1.234-2.626). In past decades, literatures revealed that the incidences of hypertension, diabetes, cardiopathy, hyper-lipidemia and hyperuricemia of Qingdao are higher than those of other areas in China. The incidence rate of fatness and overweight is also higher in china. In our study, the exposure rates of related factors in the control group are close to the incidence rates of Qingdao area reported recent years.Conclusion:1. Eight reseach items, i.e. hypertension, cardiopathy, diabetes, hyperlipidemia, hyperuricemia, overweight, smoke and drinking, are main risk factors of ischemia stroke in Qingdao area.2. Hypertension, diabetes, cardiopathy, hyper-lipidemia and hyperuricemia of Qingdao are higher. Incidence of fatness and overweight is also higher in china.3. Compared with literatures published in 1990's, the smoker group of Qingdao is not enlarged clearly. However, the smokers smoke tobacco heavier. Exposure rate of drinking is higher too. |
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