The Correlates Of Serum Levels Of EsRAGE In Patients With Type 2 Diabetic Complicating Depression, Traditional Chinese Medicine Of Liver-Qi Stagnation

Objective:To explore the Association between patients with type 2 diabetic complicating depression and serum levels of esRAGE, CRP and so on. To explore the Association between serum levels of esRAGE and traditional Chinese medicine of Liver-Qi Stagnation.Objects and Methods:According to the inclusion criteria,119 type 2diabetes mellitus patients were chosed as research objects.We chose 71 type 2 diabetic complicating depression patients as research group and 48 type 2 diabetes mellitus with normal cognitive function patients as control group. The complicating depression group including 26 males,45 females: age from 32-75 years old. The average age was 57.39±9.80 years old. Tlhe control group including 30 males,18 females; age from 48-76 years old. The average age was 63.56±7.60 years old. After the patients were brought into the research team, according to "Liver -Qi Stagnation clinical diagnosis standard" of Jin Yiqiang.The research group was divided into 29 cases Liver-qi stagnation,42 cases of non-Liver qi stagnation. All subjects were analyzed by depression scalequestionnaire(HAMD) and Liver-qi stagnation symptomsscore scale,and serum esRAGE,HbAlc,blood lipid,CRP,IMT, microa lbumin was measured, and the morbidity of diabetic microvascular complications,treatment type was recorded in every case, analyzed the association between serum esRAGE and type 2 diabetic complicating depression,and relationgship of traditional Chinese medicine of Liver -qi stagnation cognitive impairment.Results:1.There was significant difference between the group with depression and the group without depression in women,lower age,obesity,abdominal circumference,esRAGE, HbAlc, CRP,IMT (P<0.05). The morbidity of diabetic microvascular complications was higher in the group with depression than in the group without depression,but had no significant difference (p>0.05).2. Multiple linear regression analysis showed that HAMD scores was negatively correlated with esRAGE, standard regression coefficient was -0.270, p value <0.01, was positively correlated with IMT, standard regression coefficient was 0.183, p value <0.05, was positively correlated with HbAlc, standard regression coefficient was 0.314, p value<0.01,there were significant correlation. HAMD scores had no correlation with CRP.3. There was significant difference between the group with Liver-qi stagnation and non-Liver qi stagnation in esRAGE,HbAlc (p<0.05).There was no significant difference between these groups in gender,age,BMI, blood lipid,abdominal circumference,CRP,IMT (p > 0.05).4. Multiple linear regression analysis showed that Liver-qi stagnation symptoms scores was negatively correlated with esRAGE, standard regression coefficient was -0.304, p value <0.01, was positively correlated with HbA1c, standard regression coefficient was 0.302, p value <0.01,there were significant correlation.Conclusion:1.The gender,age,BMI,abdominal circumference, had diabetic complications insulin therapy in type 2 diabetes mellitus are risk factors of depression.2. Inflammation and atherosclerosis all play an important role in the pathogenesis of depression. The esRAGE was the protective factor of atherosclerosis and type 2 diabetic complicating depression.3. Liver-qi stagnation symptoms may directly affect blood glucose control in diabetic patients. The esRAGE may be blocking or partially blocking the immune response of immune cells of AGEs, to achieve the potential of Liver-Qi Stagnation.