Assessment Of Left Atrial Function By Strian Rate Imaging In Patients With Hypertension

Objective:To compare strain and strain rate in primary hypertensive patients with different configuration of left ventricular(LV) by Strian Rate Imaging(SRI), analysis the dependability of strain rate and traditional ultrasound parameter, and approach the clinical value of evaluating left atrial(LA) function by SRI.Methods:160 patients with primary hypertensions were divided into normal pattern LV (LVN,n=40) and concentric remodeling pattern LV (CR,n=40),concentric hypertrophy LV(CH,n=40),eccentric hypertrophy LV(EH,n=40),and 41 healthy participants were also included.(1)At three-chamber and four-chamber view,the strain and the strain rate curves was gained in the middle segments of each left atrial wall(left atrial anterior wall,inferior Wall,posterior wall,lateral wall and Atrial Septum) by SRI. Strain rate parameters SRs were measured during left ventrial systolic phase,SRe were measured during left ventrial diastolic early phase,SRa were measured during left ventrial diastolic later phase and max strain were measured. (2)At four-chamber view,Peak velocity during left ventrial diastolic early phase(E') and Peak velocity during left ventrial diastolic later phase (A') of each mitral annulus were measured on Tissure Doppler imaging(TDI) and then E'/A' were calculate. Peak velocity during left ventrial diastolic early phase (E) and Peak velocity during left ventrial diastolic later phase (A) of mitralis bloodstream spectra were measured on pulsed wave Doppler(PW) imaging,then E/A were calculate. (3) At four-chamber view, left atrail maximum volurne(LAVmax), left atrail minimum volume(LAVmin) and left atrial preliminary systole Volurne(LAVpre) were measured by single plane simpson way, and left atrail active ejection fraction(LAAEF) and passive ejection fraction (LAPEF) were calculated; At LV long axis view, left atrail maximum internal diameter(LAD),LV maximum internal diameter(LVDd),thickness of LV posterior wall(LVPWd) and ventricularl Septum(IVSd) were measured during LV end-diastole.Results:(1)Compared with the control group,the SRs and SRe were reduced in hypertensive group,meanwhile the SRa were higher in LVN group,CR group and CH group,and the SRa were reduced in EH group(p<0.05). (2) LAAEF increased by degree in the four group, Nomal group<LVN group<CR group<CH group (p<0.05),EH group reduced(p<0.01); LAPEF decreased progressively, Nomal group>LVN group>CR group>CH group>EH group (p<0.05).(3)The dependability of SRa and LAAEF was closely(r=0.735,P<0.01),SRe and LAPEF was closely too(r=0.579,p<0.01).(4) Compared with the control group,E'/A' were reduced in hypertensive group, E/A were reduced in CR group,CH group and EH group,but E/A were not reduced in LVN;LAD,LAVmax,LAVmin,LAVpre,LAAEF and LAPEF was higher in hypertensive group(p<0.05). (5)SR of LA with health adult walls were higher than atrial septum(p<0.05).Conclusions:(1)The SRa,SRe and SRs can acess LA function. (2)The SR parameter can reflect the change of LA function before LV reconstitute;Following development of hypertension,LA saving and tuding function were weakened,pumping function was reinforced gradually, and LA pumping function was weakened during hypertensive later period.(3)SRa and SRe of LA can assess the change of LV diastolic function sensitively during hypertensive earlier period. (4) The eformation of LA walls were higher than atrial septum.