Expression And Clinical Significance Of PD-1 In CD8~+T Cell In Gastric Cancer Patients

Objective To explore the clinical value based on the observations of the level of programmed death-1 (PD-1) on the CD8+T cell surfaces in the peripheral blood between the gastric cancer patients and the healthy controlled groups, and the relation between the PD-1 level and the cancer progressing.Methods There were 66 of gastric cancer patients in various cancer types, and 34 healthy controlled patients to obtain the blood samples and isolate PBMCs. The positive ratio of the PD-1 on the CD8+T cell surfaces in the peripheral blood was detected via the flow cytometry.Results Through analysing the peripheral blood samples between 66 of gastric cancer patients and 34 of healthy controlled patients by using flow cytometry, which indicated that the PD-1 positive ratio on the CD8+T cell surfaces in the peripheral blood of the gastric cancer patients is higher than that of the healthy controlled group. The audit results are 8.22±5.17, P<0.0 001 and 17.81±4.74, P<0.0 001 respectively. The frequencies of the PD-1 on the CD8+T cell surfaces in the peripheral blood of the various cancer patients are different, and all the audit results have statistical value.Conclusion The PD-1 positive ratio on the CD8+T cell surfaces in the peripheral blood of the gastric cancer patients is higher than that of the healthy controlled patients group, and it is in a positive relation within the various gastric cancer types.