Study On The Expression And Correlation Of RKIP And NF-κ Bp65 In Epithelial Ovarian Cancer

Objective:To investigate the expression and correlation of Raf kinase inhibitor protein (RKIP) and nuclear factor kappa Bp65(NF-κB p65) and the role and mechanism of the invision and metastasis in epithelial ovarian cancer.Methods:The expression of RKIP and NF-κBp65 were detected in 76 cases of epithelial ovarian cancer tissues,35 of epithelial ovarian benign neoplasms tissues,22 of normal ovarian tissues by immunohistochemical technology (S-P). Statistical analysis was used to compared the expression of RKIP and NF-κBp65 with clinical and pathological parameters in epithelial ovarian cancer and the correlation was analyzed.Results:1. The expression rate of RKIP in epithelial ovarian cancer, epithelial ovarian benign neoplasms and normal ovarian tissues was 28.95%,57.14%, 90.91%, RKIP expression was significant lower in epithelial ovarian cancer than that benign neoplasms and normal ovarian, the difference was significant (P<0.01).2. The expression rate of NF-κBp65 in epithelial ovarian cancer, epithelial ovarian benign neoplasms and normal ovarian tissues was 13.64%,51.43%,78.95%, NF-κBp65 expression was significant higher in epithelial ovarian cancer than that benign neoplasms and normal ovarian, the difference was significant (P<0.01).3. The expressions of RKIP and NF-κBp65 in epithelial ovarian cancer were associate with clinical staging, lymphnode metastasis and tumor differentiation(P<0.05), They are not statistically significant with the expression of different groups and pathological types (P> 0.05)4. RKIP expression was negatively correlated with NF-κBp65 (r=-0.582) in the epithelial ovarian cancer. Conclusions:1. Reduced expression of RKIP in epithelial ovarian cancer, while NF-κBp65 was abnormal activation, They maybe participate the occurrence of epithelial ovarian cancer.2. The expression of RKIP is lower with tumor differentiation, cli-nical staging and lymphnode metastasis, The results indicate that RKIP play an important role in inhibitor invision and migration of epithelial ovarian cancer.3. The expression of NF-κBp65 is higher with tumor differentiation, clinical staging and lymphnode metastasis, The results indicate that RKIP play an important role in promoting invision and metastasis of epithelial ovarian cancer.4. There was negative correlation between the expressions of RKIP and NF-κBp65 in epithelial ovarian cancer; Probably, The mechanism maybe activity the NF-κB signaling pathway and promoting invision and metastasis of epithelial ovarian cancer.