Diagnosis And Treatment Research Of Choroid Plexus Tumors

Objective:To investigate the diagnosis and treatment of Choroid plexus tumors in order to elevate the rate of diagnosis and total resection and also improve the prognosis of patients.Materials and Methods:A retrospective analysis of the case records of 31 patients operated for CPT betiwn 2002 December and 2010 October and their clinical datas and prognosis were retrospectively analyzed and evaluated.Results:The study group included 26 (%) cases of choroid plexus papilloma (CPP),04 (36%) cases of choroid plexus carcinoma (CPC) and 1 cases of atypical CPP. The mean age at presentation was 37years and a male preponderance was noted (20:11). The tumors were distributed as follows:lateral ventricle (20; 64%), fourth ventricle (8; 20%), fourth ventricle with cerebellopontine angle extension (1; 12%), and Brain Parenchyma (2; 4%).A complete surgical excision was achieved in 21 cases of CPP and 2 cases of CPC. Operative complications include pneumocephalus(29%), subdural effusion (16%), and persistent hydrocephalus requiring shunt (3.2%). All patients with CPP had a good outcome at the end of a mean follow-up of 6 monthe to 12 years, whereas the CPC had a bad outcome.Conclusion:CPTs include a spectra ranging from CPP to CPC. Radiologic and histologic characterization of these tumors is difficult and newer immunohistochemical and genetic studies should be done to differentiate them from each other. Total excision offers a good prognosis and should be attempted for all forms of CPTs. CPPs carry a good prognosis, and adjuvant therapy is not indicated even after partial excision. CPCs and atypical CPCs carry a poor prognosis, and adjuvant therapy improves survival marginally after total excision. Spinal drop metastases are common for CPC and screening of the spine for possible metastasis should be part of the routine preoperative and postoperative investigation protocol.