Experimental Observation Of The Bone Remodeling Mechanism And Applied Research On The Bionic-topology Optimization

As the supporting parts of the whole body, bone takes very important role in the lifecircle by helping the body to make a movement. Bone is consists of the original geneticrelationship, in the biomechanical environment, optimize it's topology by bone remodeling,osteoblasts and absorption of the bone. Thus, create the dynamic stable structure and thetopology shape of the skeletal system. Therefore, studying on the bone formation, growth andshaping not only provide the necessary scientific basis for the modern biomechanics, medialand clinical research, also can provide the reliable parameters for bionic topologyoptimization methods and actual project applications.In this study, starting from the experimental study, introduced the self-repairing bonedefect based on the bone remodeling mechanism and the experimental observation andanalysis in detail. The experimental result shows that:1)The self-repairing of the bone defect of young rabbit is much faster than the adultrabbit, in this repairing process, there are exist strong instability between bone layers. And thisinstability comes from imbalances and the strong changes of the osteoclasts and osteoblastswhich can result in the bone formation and absorption behavior.2)Regardless of the adult rabbits or young rabbits, the interaction phenomenon which isone increased and another one is decreased between the spongy bone and enamel bonevolume during the self-repairing process with bone defect is obtained. This phenomenonsuggests the following two points: First, the reaction-diffusion phenomenon between bonecells; second, osteosclerosis phenomenon。In this study, also studied the bone remodeling reaction diffusion models are studied andthe bionic-topology optimization method is established by coupling with the finite elementmethod and the bone remodeling model based on the reaction-diffusion equation. The bonemicro structure and whole femur shape forming process are implemented by using thenumerical simulation based on the bionic-topology optimization method which considered the mechanisms of osteoblasts and osteoclasis. The validity of iBone3D method on bone microstructure and whole bone shape bionic-optimization process are proved.