Preparation Of Sodium Alginate And Its Derivative Nanofibers By Electrospinning And The Study Of Their Properties

Alginate is a natural polysaccharide, with pharmacologic agents accessories required stability, solubility, viscosity and safety, excellent biocompatibility, and controllable biodegradability, the tissue scaffold materials are widely used in medical field. But as a result of sodium alginate as the polyelectrolyte, aqueous solution with high conductivity, alginate anion chain between strong repulsive force, hindered the chain and the chain of each winding, the alginate is difficult to electrostatic spinning nano fiber, the electrospun nanofibers applied to good biocompatibility, and controllable degradation performance drug carriers limited. This article through sodium alginate sodium and is easy to be electrospun polyvinyl alcohol (PVA) blend, successful electric spinning with the sodium alginate nanometer fiber.This paper studies the content of sodium alginate on electric spinning solution properties and nano fiber morphology, electric spinning process parameters, including spinning voltage, receiving distance, spinning speed on the fiber morphology of the impact, and ultimately determine the electric spinning solution the optimal concentration of2%sodium alginate solution and8%PVA solution according to the ratio of3:7optimal blending, spinning voltage is15KV, the best receiving distance15cm, the best spinning speed is0.3ml/h.Ultrafine fibers and fiber mats of Poly(vinyl alcohol)mixed with alginate containing a small amount of NaCl, acetic acid, or surfactant sodium dodecyl sulfate (SDS) were prepared by electrospinning of their blend aqueous solution. Study the impact of the solution and fiber properties by a small amount of additives. Finally, solution electric spinning mechanism is discussed preliminarily. The results show that the NaCl change the conductivity and viscosity of the solution, the viscosity of the solution containing acetic acid is decreased, the volatility of the solvents is increased, the SDS reduces the surface tension of the solution, proper amount of material is added and the morphology of fibers is improved. The chemical structure of electrospunning fibers is not influenced essentially. Inorganic ions make the fibers being stretched strongly, the surface of the droplet at the Taylor taper is affected by a number of the forces, such as the static electric repulsion, the surface tension and the intermolecular hydrogen bonding force coming from the same polymer molecules and the polymers with different molecular and the polymers with the solvent such as water. These kinds of forces decide the success of electrospunning polymer solution, The addition of the different substances by changing these forces to influence the solution electro-spinning performance.Through sodium alginate with laborious amine reaction of sodium alginate, hydrophobic modification, preparation of alginate derivatives with PVA composite electrostatic spinning. Sodium alginate derivatives on molecular weight and molecular weight distribution, FTIR analysis,lHMR analysis showed that the sodium alginate with different degree and toa occurs the condensation reaction, and the study of alginate derivatives with PVA blend of the best ratio of2%alginate derivatives with8%PVA according to2:8blend, derivatives and increase the hydrophobicity blend solution viscosity somewhat reduced, but its conductivity is still large, show that the polyelectrolyte. Through SEM observation of fiber morphology, showed that alginate derivatives with PVA blend solution can be electrospun fiber, but easy to appear more bead wire. The electrospun fiber infrared characterization, thermal analysis indicates that, in the process of power spinning alginate derivatives with PVA occurs some intermolecular forces, fiber structure without essential change, electrospun fiber melting temperature of200℃, the thermal decomposition temperature of231℃. By the end of the alginate/PVA and derivatives/PVA fiber in water was observed and the contact angle test showed that sodium alginate derivatives, electrospun nanofibers were electrospun fiber hydrophobic alginate got bigger promotion.