Study On Synthesis Of 4-chloro-4'-fluorobutyrophenone And 1-substituted Phenyl-2-pyrrolidone

In this paper,4-chlorobutyryl chloride was synthesized by using y-butyrolactone as raw materials. On that basis,4-chloro-4'-fluorobutyrophenone,1-substituted phenyl-2-pyrrolidone were synthesized and characterized.Anhydrous zinc chloride as the catalyst,4-chlorobutyryl chloride was synthesized by the reaction of y-butyrolactone and thionyl chloride, the yield was 86.9%. The opt-imal reaction conditions were as follows:n(y-butyrolactone):n(thionyl chloride)=1:1.2, n(y-butyrolactone)=0.25mol, anhydrous zinc chloride 1.2g, thionyl chloride was dropped in 30min, reacted at 80℃by 6h.Anhydrous aluminum chloride as the catalyst, CH2Cl2 as solvent,4-chloro-4'-fluor-obutyrophenone was synthesized by F-C reaction of fluorophenyl and 4-chlorobutyryl chloride, the yield was 86.9%. The optimal reaction conditions were as follows:n(flu-orophenyl):n(4-chlorobutyryl chloride)=1:1.05, n(fluorophenyl)= 0.050mol, Anhydrous aluminum chloride 8.68g,4-chlorobutyryl chloride was dropped by ice bath in 30min, the reaction was at room temprature for 4h.Triethylamine as acid deposition,4-chloro-(N-phenyl)-butyramide was synthesized by aniline and 4-chlorobutyryl chloride. benzyl triethyl ammonium chloride as phase t-ransfer catalyst,1-phenyl-2-pyrrolidone was synthesized by nucleophile NaOH and 4-c-hloro-(N-phenyl)-butyramide. Total reaction time was 1.5h, the total yield was 87.6%. 1-(p-totyl)-2-pyrrolidone, 1-(o-totyl)-2-pyrrolidone, 1-(4-nitrophenyl)-2-pyrrolidone, 1-(2-chlorophenyl)-2-pyrrolidone were synthesized in similar ways, total reaction time was 1.5h,4h,8h,4h, total yield was 81.3%,48.2%,64.2%,48.8%. The influence on rea-ction activities made by lacation and type of Substituents on Substituted aniline were discussed.