Study On The Organic Reaction Promoted By Manganese Aceate And Their Application

During the past decades, Manganese(Ⅲ) acetate mediated free-radical reactions have emerged as important synthetic methods for a new bond formation. Free radical reactions have become increasingly important, as well as a very attractive tool in organic synthesis due to their powerful, selective, specific and mild reaction abilities.This thesis contains three parts: (1) Mn(OAc)₃·2H₂O promoted cyclic 1,3-dicarbonyl compound to react with nitroalkenes to synthesize dihydronfuran derivatives, which were further deoxidized of the nitro-group to obtain varies of N-hydroxypyrrole derivatives with high yields. (2) Mn(Ⅲ)-Cl is formed by the reaction of Mn(OAc)₃ and hydrochloric acid in HOAc, which could effectively chlorinate with conjugated alkenes to afford chlorinated organic compounds in good yields under mild conditions. (3) Arylphosphonic acids are coupling with alkenes catalyzed by Pd(OAc)₂ involving cleavage of a carbon-phosphorous bond .The structures of products were confirmed by 1H NMR, 13C NMR and HRMS spectra. And the possible mechanism was proposed based on these spectra data.