Research On The Asymmetric Transfer Hydrogenation Of 2-aroyl-1-tetralones And Bis(aroylmethyl)sulfones And Sulfides

1. Asymmetric Transfer Hydrgenation of 2-Aroyl-1-tetralones via Dynamic Kinetic ResolutionThe dynamic kinetic resolution of 2-aroyl-1-tetralones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl(p-cymene)TsDPEN (TsDPEN = N-(tosyl)-1,2-diphenylethylenediamine) in formic acid/triethylamine (5:2), afforded the desired products in good yields (up to 85%) with diastereomeric ratio (up to >99:1) and high enantiomeric excesses (up to >99%).2. Investigation on the Asymmetric Transfer Hydrgenation of Bis(aroylmethyl) sulfones and SulfidesWe synthesized a series of bis(aroylmethyl)sulfones and sulfides, wich underwent symmetric reduction by using HCOOH:Et3N = 5:2 system as the hydrogen source and (S,S)-TsDPEN based Ru (II) catalyst, providing the corresponding chiral diols in good yields (up to 97%) with diastereomeric ratio (up to 99/1) and high enantiomeric excesses (>99%).