Research On Iron/Copper-cocatalyzed C-o, C-N Coupling Reaction And Copper-catalyzed Coupling Reaction Of Terminal Alkyne

C-O, C-N bond and 1,3-diyne are both the invaluable structures in organic synthesis, so it benefits to develop a convenient and efficient method to construct these structures. The thesis consists of the following two sections.1. C-O, C-N bond have always been a vital part in many natural pharmaceticals, drug and electronical materials, and thus synthesis method of C-O and C-N is critical due to its widely application in constructing a series of structural units in natural product, pharmaceticals, drugs for plants and material chemistry. Traditionally, the Ullmann coupling reaction promoted by copper salts is powerful tool for the formation of C-O and C-N bond, but the reaction usually needs electron-rich ligands and stoichiometric amount of copper salts. To overcome those disadvantages, our group explored a new facile and efficient iron/copper-cocatalyzed C-O, C-N cross-coupling reaction.2. The structure of 1,3–diyne exists in many organic intermediates and natural medicines. The copper-mediated homecoupling reaction is an alternative and promising strategy. However, it usually needs stoichiometric amount of copper salts, high temperature, excessive oxidants or have low to moderate yields to aliphatic diynes. For these reasons, we report an environmentally friendly, economic and efficient system.