Several Of The Pd-catalyzed C-c Bond To Build A Reaction

In 2010, the three scientists Richard F. Heck, Ei-Ichi Negishi, and Akira Suzuki shared the Nobel Prize in Chemistry for their distinguished contribution to Pd-catalyzed cross-coupling reactions in organic synthesis. During the past several years, we have also focused on the Pd-catalyzed C-C bond formations which mainly contain the following work. I) Pd-catalyzed decarboxylative ketonization of aromatic carboxylic acids with nitriles; II) Pd-catalyzed decarboxylative allylation and Heck-type cross-coupling of carboxylic acids with allylic halides and esters; III) Pd-catalyzed direct olefination of unactivated arenes with allylic esters and ethers.In the first chapter, we reviewed the Pd-catalyzed C-C bond formations. Their importance, mechanisms, and applications in organic synthesis were also demonstrated in details.In the second chapter, we introduced the developments of Pd-catalyzed ketonization of arenes, allylation of arenes, and Heck-type cross-coupling reactions.In the third chapter, an efficient Pd-catalyzed decarboxylative ketonization of aromatic carboxylic acids with nitriles was described here. The modifications of the typical reaction conditions and substrate studies were also demonstrated.In the fourth chapter, an efficient Pd-catalyzed decarboxylative allylation of aromatic carboxylic acids with allylic halides was demonstrated here. We also described the modifications of the typical reaction conditions, substrate studies, and mechanisms in details.In the final chapter, we described a very efficient Pd-catalyzed direct Heck-type cross-coupling reaction of unactivated arenes with allylic esters and ethers. The modifications of typical reaction conditions, substrate studies, and the mechanisms were also demonstrated here.