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Study On Synthesis, Structure, Biological Activity Of Polynuclear Copper(Ⅱ) Complexes Bridged By μ-oxamido

Posted on:2012-07-05Degree:MasterType:Thesis
Country:ChinaCandidate:L Y JiangFull Text:PDF
GTID:2211330338964792Subject:Pharmaceutical Engineering
Abstract/Summary:PDF Full Text Request
In order to find anticancer complexes with high activity, we synthesis a series of complexes and obtain four new single crystals: [Cu4(dmoxba)2(bpy)2(CH3OH)2](pic)2·2H2O (1), [Cu4(dmoxba)2(phen)2](pic)2·2CH3- OH (2), [Cu4(dmoxba)2(phen)2](ClO4)2·2CH3OH (3), [Cu2(heap)(tpa)2]n (4). Then the four complexes were characterized by means of X-ray single crystal diffraction, elemental analysis, molar conductivity, IR and UV, and so on.We carry out the work from the following three sections:1. We synthesize four complexes: [Cu4(dmoxba)2(bpy)2(CH3OH)2](pic)2·2H2O (1), [Cu4(dmoxba)2(phen)2](pic)2·2CH3OH (2), [Cu4(dmoxba)2(phen)2] (ClO4)2·2CH3OH (3), [Cu2(heap)(tpa)2]n (4). All of the four complexes are new, and [Cu2(heap)(tpa)2]n (4) is the first one-dimensional copper(II) coordination polymer which is bridged both by N,N'-bis(substituent)oxamides with hydroxyl coordinating and terephthalic acid2. Interest in the studies on transition metal complexes with DNA binding properties has stimulated we exploring the binding properties of the four complexes to herring sperm DNA (HS-DNA) which were studied using UV-visible (UV-vis) absorption spectroscopy titration, fluorescence titration, ethidium bromide (EB) displacement experiments and voltammetry. The results indicate that all of the four complexes binding to herring sperm DNA (HS-DNA) with an intercalative mode.3. The cytotoxicities of the four copper(II) complexes were tested in vitro by Sulforhodamine B (SRB) assays against SMMC-7721 and A549 cell lines. All of the four complexes exhibit cytotoxic effects against the two cell lines, with the IC50 = 21 ng/mL, 36 ng/mL; 33μg/mL, 29μg/mL; 35 ng/mL, 41μg/mL and 27μg/mL, 32μg/mL, respectively.
Keywords/Search Tags:μ-oxamido, Crystal Structure, DNA Interaction, Cytotoxicities
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