Biphasic (o / W) Recognition Chiral Extraction Kinetics Of Aromatic Acid Enantiomers

In this paper, a new chiral extract separation technique-biphasic (O/W) recognition chiral extraction was applied to investigate the kinetic mechanism of benzylsuccinic acid enantiomers, a- Cyclohexyl mandelic acid enantiomers and naproxen enantiomers. The experiments were carried out under the optimized system to provide theoretical bases and technique parameters for enantioseparation process. The main contents and results can be summarized as follows:(1). The kinetics of biphasic (O/W) recognition chiral extraction of benzylsuccinic acid enantiomers was investigated to determine the extraction mechanism. Study on the reactive extraction kinetics of phenylsuccinic acid enantiomers using a modified Lewise cell, with hydrophobic tartaric acid derivative in organic phase and hydrophilic hydroxypropyl-?-cyclodextrin (HP-?-CD) in aqueous phase as chiral selector; the mass transfer rate was chosed as the benchmark. The effects of agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, initial extractants concentration of HP-?-CD and L-IBTA, pH of aqueous phase on initial extraction rate were separately researched.The experiment results demonstrate that, the kinetics of the extract reaction is fast with the values of Has and HaR were 5.9 and 4.2 respectively; and the effects of agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, initial extractants concentration of HP-?-CD and L-IBTA, pH of aqueous phase on the chiral separation ability was significant. The reactions are found to be first order with respect to PSA enantiomers and second order with respect to Chiral extractants with the forward rate constants of 1.6×10-4 m6/(mol2·s) for R-PSA and 3.3x10-4 m6/(mol2·s) for S-PSA.(2). The kinetics of biphasic (O/W) recognition chiral extraction of a- Cyclohexyl mandelic acid enantiomers was investigated to determine the extraction mechanism. Study on the reactive extraction kinetics of a-Cyclohexyl mandelic acid enantiomers using a modified Lewise cell, with hydrophobic tartaric acid derivative in organic phase and hydrophilic hydroxypropyl-?-cyclodextrin (HP-?-CD) in aqueous phase as chiral selector; the mass transfer rate was chosed as the benchmark. The effects of agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, initial extractants concentration of HP-?-CD and D-IBTA, pH of aqueous phase on initial extraction rate were separately researched.The experiment results demonstrate that, the kinetics of the extract reaction is fast with the values of Has and HaR were 6.98 and 7.14 respectively; and the effects of agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, initial extractants concentration of HP-?-CD and D-IBTA, pH of aqueous phase on the chiral separation ability was significant. The reactions are found to be first order with respect to a-CHMA enantiomers and second order with respect to Chiral extractants with the forward rate constants of 6.54×10-4 m6/(mol2·s) for S-a-CHMA and 6.84×10-4 m6/(mol2·s) for R-a-CHMA.(3). The kinetics of biphasic (O/W) recognition chiral extraction of Naproxen enantiomers was investigated to determine the extraction mechanism. Study on the reactive extraction kinetics of Naproxen enantiomers using a modified Lewise cell, with hydrophobic tartaric acid derivative in organic phase and hydrophilic hydroxypropyl-?-cyclodextrin (HP-B-CD) in aqueous phase as chiral selector; the mass transfer rate was chosed as the benchmark. The effects of agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, initial extractants concentration of HP-?-CD and L-IBTA, pH of aqueous phase on initial extraction rate were separately researched.The experiment results demonstrate that, the kinetics of the extract reaction is fast with the values of HaR and HaS were 13.27 and 9.33 respectively; and the effects of agitation speed, interfacial area, initial enantiomers concentration in aqueous phase, initial extractants concentration of HP-?-CD and L-IBTA, pH of aqueous phase on the chiral separation ability was significant. The reactions are found to be first order with respect to PSA enantiomers and second order with respect to Chiral extractants with the forward rate constants of 1.26×10-4 m6/(mol2·s) for S-NAP and 2.52×10-4m6/(mol2·s) for S-NAP和R-NAP.