The Effect Of The Hypoxic On Some Indices Of Blood For The Ochotona Curzoniae And The Microtus Oeconomus

As an emergency factor hypoxia affects many physical functions, especially in cardiovascular system. The Ochotona curzoniae is the advantages of the Tibetan Plateau alpine meadow species, Ochotona curzoniae and Microtus oeconomus through the generations of selection, the formation of a good high altitude adaptation mechanism has been recognized as the best to adapt to high altitude hypoxia species .All functions of the body have been changed such as the cardiovascular system. We adopt physiological and histological method to measure changes in physiological function and histological structure and to explore the mechanism of hypoxia adaptation in cardiovascular system of the small mammals. The results are as follows:1. By blood gas analysis showed that Ochotona curzoniae and Microtus oeconomus of hemoglobin (Hb), hematocrit (Hct), carbon dioxide partial pressure (P_co2) all over the prolongation of hypoxic exposure time increased partial pressure of oxygen (P_o2) decline;And in the same conditions, the three indicators of Microtus oeconomus is higher than the Ochotona curzoniae. As the hypoxic exposure time longer, as well as elevation of the Ochotona curzoniae of the oxygen dissociation curve gradually shifted to the left, while the Microtus oeconomus is shifted to the right (Figure 5). This may mean that Ochotona curzoniae in the condition of hypoxia in the oxygen affinity is higher than the Microtus oeconomus. Either normoxic or hypoxic control group, the Ochotona curzoniae to the organization's ability to release oxygen are stronger than the Microtus oeconomus.2 . Through the blood routine analysis showed, In the process of hypoxia adaptation ,The number of red blood cell (RBC), hemoglobin concentration (HGB) and hematocrit (HCT) are significantly higher after hypoxia adaptation in the Ochotona curzoniae; however, its mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) decrease after hypoxia adaptation. The high RBC, HGB and HCT as well as lower MCV, MCH and MCHC in experimental animals are a possible approach to adapt the hypoxia environment. In the same conditions, each of the Microtus oeconomus'blood routine indicators were higher than the Ochotona curzoniae'almost. 3.The experimental results showed that with increasing altitude and hypoxia exposure time increases, the HW / BW, RVW / BW, LVW / BW, RVW / LVW of Microtus oeconomus and Ochotona curzoniae have shown an upward trend, While in the same conditions, the Microtus oeconomus'HW / BW, RVW / BW, LVW / BW, RVW / LVW higher than Ochotona curzoniae.4.By biochemical analysis, along with the increase of hypoxia and hypoxia simulated altitude exposure time increases, Ochotona curzoniae and Microtus oeconomus of the total protein (TP), lactate dehydrogenase (LDH) of the upward trend; carbon dioxide combining power (T_CO2) have shown a downward trend. Hypoxia in the same environment, the Ochotona curzoniae of the AST / ALT, T_CO2 two indicators higher than the Microtus oeconomus.In brief, the Ochotona curzoniae and the Microtus oeconomus are adapted to hypoxic habitats and organism maintains the stable internal environment by different responses in the individual, organs and cells. Its cardiac compensations have been greatly developed by improving the function of blood and the capability of taking and using oxygen, enhancing cardiac reserve, increasing myocardial contractive. Putting together the facts mentioned above, it can alleviate the hypoxia effects on cardiac functions.