Application Meta-analysis To Evaluate The Expression Of The P53 Gene In Triple Negative Breast Cancer

Purposes : To explore the relationship between p53 gene and triple-negative breast cancer, and determine that whether p53 gene could be a new effective tumor marker.Materials and methods:We identified studies with quantitative data on the relation of P53 gene and TNBC through searching 12 databases on line (Oct. 1999 - Oct. 2009) and reviewing the references, which were written in English or Chinese. Summary estimates of odds ratio was calculated using the fixed-effects model or the random-effects model as appropriate.Results:We identified 12 eligible studies with 1532 cases of TNBC patients and 6329 controls of non-TNBC patients. The test for homogeneity resulted inχ2=200.16 (P<0.05), it showed significant heterogeneity so that a random effect model was applied. Our results showed that the expression of p53 gene could be much stronger in TNBC group than that in non-TNBC group (OR=2.10, 95%CI=1.21-3.65). In ethnicity-subgroup analysis, we found that in Caucasian group, the expression of p53 gene were stronger in TNBC group (OR=2.60, 95%CI=1.21-5.57), but there was no statistical significance in Asian group (OR=1.69, 95%CI=0.83-3.45).Conclusions:p53 gene could be an effective predictor and a good therapeutic target for TNBC patients in the future, especially in Caucasian. Further researches focusing on p53 gene would gain a breakthrough in the treatment of TNBC.