| Objective: Antidepressants scattered through the observation of unpredictable chronic mild stress rat model of depression behavior and serum T3, T4, TSH effects of antidepressants casual study of animal model of depression, the effects of HPTA in order to investigate the bulk Pharmacodynamics mechanism of antidepressants on depression.Methods: Using a variety of chronic unpredictable mild stress model of depression in rats, normal group, model group, Fluoxetine group, antidepressants, scattered large, medium and small dose group, 21 days for treatment, periodic determination of each group rat body weight, sugar consumption and behavior change, and RIA determination of serum T3, T4, TSH concentration change.Results: Compared with the normal group, model group rats lost weight, vertical and horizontal reduction in the number of sports, to reduce consumption of dessert, there is significant difference (P<0.05), model group, serum T4 levels were significantly increased, TSH levels rise, there is significant difference (P<0.05); T3 levels decreased, no significant difference(P>0.05).Compared with model group, antidepressants scattered large ,medium and small dose group and the Fluoxetine group, can study the behavior of rats markedly improved, the restoration of nearly normal levels, there is significant difference (P<0.05), serum T4 was significantly lowering, TSH values decrease, there is significant difference (P<0.05), and T3 of the values decrease, no significant difference (P>0.05); Compared with model group, antidepressants Powder dosage group can obviously improve the rat's behavioral characteristics, so that blood clearance of T4, TSH levels significantly decreased, T3 levels increased significantly, there was a significant difference (P <0.05 ).Conclusions: Antidepressants can improve the dispersion characteristics of rat behavior, so that the value of serum T3 was increased, T4, TSH values decreased to restore near normal levels, the mechanism of antidepressants may be associated with regulation of HPTA scattered dysfunction related to antidepressants scattered on clinical treatment for depression and provide a theoretical foundation. |
