Uric Acid Levels And Metabolic Syndrome-related Research

Study 1 Relationship of serum uric acid concentration with metabolic syndrome and its componentsObjective To investigate the relationship between uric acid and metablolic syndrome and its components.Methods A population-based and cross-sectional survey was performed in 9 provinces and 15706 individuals with detailed information were collected.MS was defined by the joint committee of dyslipdemia criterion.Multiply logistic regression analysis was used to determined the relationship between uric acid and metabolic syndrome and its components.Results(1) the prevalence of hyperuricemia was significantly higher in MS group than those in non-MS group(P＜0.0001),not only in MS group but also in non-MS group man had a higher proportion of hyperuricemia than female(2) the level of uric acid was increasing with the number of the components of MS in both sexes(liner trend for p＜0.0001)(3) The prevalence of MS was 11.94%,14.94%,19.33%,34.44%across the interquartiles(P trend＜0.0001).(4) Correlation analysis demonstrated that serum uric acid level was positively correlated with triglyceride,creatinine,BMI,waist,total cholesterol but negatively with HDL-C.(5) After adjusting for age,sex,smoke,drink,BMI,TC,TG,creatinine,fasting glucose, people with an increased per unit was 0.99 times to have MS;while dividing the participants into two groups,people in the hyperuricemia have 22%higher risk to have MS;while comparing with the lowest group,the OR and its 95%CI was 0.95(95%CI:0.81-1.10),0.97(95%CI:0.83-1.12) and 1.20(95%CI:1.02-1.41), respectively.(6) With the increase of the level of uric acid,the proportion of hypertension,central obesity,high triglyceride,abnormal glucose increased significantly(P＜0.0001).the same trend was seen in level of uric acid across differnce blood pressure and BMI categorities(P＜0.0001).(7) people in the hyperuricemia have 19%higher risk to have hypertension,109%to have obesity,277%to have eleveted triglyceride,38%to have lower HDL-C,50%to have abnormal fasting glucose.Conclusion Serum uric acid intimately related with metabolic syndrome and its components such as obesity,dyslipdemia and so on.And high uric acid level may be an important factor for development and progress of MS. Study 2 Correlation analysis of serum uric acid and prehypertensionBackground Hyperuricemia is frequently seen in hypertensive patients.Previous experimental and clinical studies have proved that elevated serum uric acid is associated with increased risk for developing hypertension,Whereas,little information on the relationship between serum uric acid and prehypertension is reported.Objective The purpose of this research is to evaluate the association between the serum uric acid and prehypertension.Method 7839 subjects without hypertension and other cardiovascular diseases were selected from a representative cross-sectional study in urban district and the relevant village of 9 provinces during 2005-2006.For grouped analyses,individuals were classified according to approximately equal quartiles of serum uric acid for the entire study population(<209μmol/L,209～262μmol/L,262～324μmol/L,>324μmol/L for overall population,<250μmol/L,250～306μmol/L,306～366μmol/L,>366μmol/L for male,<193μmol/L,193～236μmol/L,236～285μmol/L,>285μmol/L for female).The odds ratio for prehypertension was calculated for each uric acid level with the lowest quartile as the reference using multivariable logistic regression models.Result The prevalence of prehypertension increased with increasing uric acid categories (P<0.0001),Similar trend was found in female population(P=0.04) but not in male participants(P=0.66).For both gender,DBP,GLU,serum creatinine levels,BMI,TG,TC all increased with increasing serum uric acid(all p<0.01).After adjusting for age,sex, smoking,drinking,LDL-C,HDL-C,serum creatinine,triglyceride,total cholesterol, GLU,body mass index(BMI),the multivariable odds ratio(OR)[95%confidence intervals(CI)]comparing quartile 4 of uric acid(>324mmol/l) to quartile 1(<209mmol/l) was 1.3(95%CI:1.1～1.5),P trend=0.03.Conclusion Serum uric acid may be independently associated with the increasing rate of prehypertension in people without hypertension and cardiovascular disease. Study 3 prevalence rate of hyperuricemia and risk factors of cardiovascular disease in population aged 30-70.Objective:To investigate the prevalence of hyperuricemia and its risk factors in the adult population aged 35-70 years.Method:To analyze data of 15706 residents from the cross-sectional survey.Physical examination was carried out and fasting blood was tested.Multivariate Logistic regression models were used to determine the risk factors.Result:(1) The prevalence of hyperuricemia was 12.08%,14.59%for man and 10.21% for women,respectively(P<0.0001).The mean level of uric acid in males was higher significantly than that in the females[(322.33±133.11),(255.61±100.49)](2) The prevalence of hyperuricemia increased with the age(Ptrend<0.0001).Similar trend can be seen in female population((Ptrend <0.0001),but not in the male population.(3) The main concomitant diseases of hyperuricemia were hyperlipemia(80.4%),then overweight and obesity(74.61%),elevated blood pressure(58.32%),abdomen obesity (45.47%),diabetes(11.80%).(4) In a multivariate logistic regression model,age(OR=1.01,95%CI:1.01-1.02),male gender(OR=1.36,95%CI:1.21-1.53),obesity(OR=1.69,95%CI:1.52-1.88), hypertriglyceridemia(OR=4.28,95%CI:3.84-4.76),hypercholesteremia(OR=1.19, 95%CI:1.06-1.33),elevated blood pressure(OR=1.17,95%CI 1.05-1.30),drink (OR=1.36,95%CI:1.19-1.56) were associated with increased risk of hyperuricemia.Conclusion:Hypertriglycedemia,hypercholesteremia,male gender,elevated blood pressure,obesity,drink are associated with increased risk of hyperuricemia.Decreasing the level of triglyceride may be an effect ways to prevent hyperuricemia and its related diseases.