| Purpose:To work through the isolated rat heart model, myocardial ischemia model, blood plate aggregation model observation ginseng saponins on animal flower hemodynamics, blood biochemistry, blood pool effects of ginseng flower explore Saponins on cardiovascular system function as well as the protective effects of myocardial ischemia, to explore its mechanism, and in-depth study huoxuehuayu chest therapy certification at the impact of myocardial mechanism. chanism.Method:The isolated rat hearts were prepared and the effects of Ginseng total saponins Flower on arterial blood pressure(AP),±dp/dtmax, left ventricular systolic pressure (LVSP),Cardia coutput(CO),left ventricular end-diastolic pressure (LVEDP) and heart rate (HR) were observed. The heart model of ischemia-reperfusion injury were built by isolated working heart perfusion technology.Set up the use of coronary artery ligation rat model To observe the effects of Ginseng total saponins Flower on CK, LDH, SOD, MDA.5‵-adenosine diphoshate disodium salt ADP to promote aggregation agent,platelet aggregation model set up to observe the flower ginseng saponins on rabbit platelet aggregation rate,and the use of electrical stimulation of rat carotid artery thrombosis the formation of law,observe the flower of different doses of ginseng saponins on the intra-arterial thrombosis(blocked artery)time (OT)impact To further explore its ginseng total saponins in the flower huoxuehuayu aspects of pharmacological researchResult:The total saponins of Panax ginseng flower may be a dose-dependent manner in vitro work to enhance cardiac funtion indicatorsAP ,LVSP,dp/dtmax, dp/dtmax,slowHR increased cardiac output CO;ginseng total saponins in vivo Flower delivery can reduce the myocardial ischemia model of animal serum CK ,LDH content and enhance the vitality of ischemic myocardial SOD,lowerMDA content;Flower Ginseng Saponins on ADP-induced platelet aggregation significantly inhibited;ginseng total saponins can flower animal thrombosis formation(blocked artery)Time (OT) was signficantly longer,namely thrombosis significantly inhibited.Conclusion:The ginseng saponins on animal flower hemodynamic adjustment to enhance myocardial contracility, increasing cardiac output,and there is dose-dependent.Flower Ginseng Saponins on myocardial ischemia model of myocardial injury has a protective effect,could decrease serumCK,LDH levels increase in myocardialSOD content ,reduceMDA content.Ginseng total saponins Flower delivery in vitro on platelet aggregation inhibition has its rate of Flower Ginseng total saponins high does can be significantly prolonged electrical stimulation of rat carotid artery thrombosis time (blocked artery),indicating that ginseng total saponins inhibit flower thrombosis... |
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