Different Sports Model Induced Stress Ulcer And Licorice Prevention Of Experimental Research

In this paper,by observing the movement of various effects of stress-induced gastric ulcer is to investigate the different exercise intensities on the incidence of stress-induced gastric ulcer What is the difference between,for the establishment of a scientific and exhaustive exercise-induced fatigue model based on biology:explore the exercise stress pathological mechanism of gastric ulcer and licorice on the stress-induced gastric ulcer in rats.First of all,the establishment of the experimental campaign fatigue and exhaustion model, before and after exercise stress observed behavioral changes in rats;detected in rats after exercise stress ulcer index Proventriculus organizations;measured by radioimmunoassay using rat motilin (MOT) content to determine the lipid peroxidation product of MDA content and antioxidant enzyme SOD,H~+,K~+ -ATPase,total ATPase,such as reflected in indicators of free radical defense system,as well as the hypothalamus and Proventriculus nitric oxide synthase(NOS) and acetylcholine transferase(CHAT) in two important neurotransmitter-related enzyme activity changes.The Results Show:1.The use of open-field,cassette,tail suspension test behavior detection methods increased the load on the six-week campaign before and after exercise in rats and to observe the adaptive behavior. Found that rats eating campaign fatigue increased,little change in body weight,irritability,hair messy Matte,horizontal and vertical movement capacity are increased,decreased adaptability cassette;movement Exhaustive rats significantly reduced food intake,body weight decreased individual;make them apathetic,eyes blurred,often nap,unresponsive,bowel,Matte messy hair, loss of appetite,fatigue expression,disheveled fur,slow response to outside stimuli,the capacity of horizontal and vertical movement weakened,poor adaptability cassette.Six-week exercise increased fatigue and exhaustion caused by the state of animal behavior and performance indicators of physiological and biochemical changes in rats a positive correlation,provided that the experimental animal model of fatigue and exhaustion is reliable.2.High-intensity exercise-induced fatigue and exhaustion caused stress-induced model of gastric ulcer,ulcer extent increased with increasing exercise intensity.Fatigue model is the only mucosal surface ulcers,gastric erosions appeared punctate,multiple bleeding points,hyperemia,edema and so on;exhaustive model of ulcers can be deep muscularis mucosa to submucosa vasodilation, glandular disorder,a sharp increase in ulcer index,which is pathological injury on exercise-induced fatigue and the existence of essential differences between exhaustive.3.The study found that stress-induced ulcers of the major mechanisms:stress,nerves - the endocrine system disorders,sympathetic - adrenal medulla and the hypothalamus - pituitary - adrenal axis(HPA)â…¡strongly excited.Sympathetic - adrenal system so excited about the continued contraction of intra-abdominal blood vessels,leading to intra-abdominal organ ischemia,mucosal erosion,ulcers,bleeding.Excited when the HPA stress axis can produce central effects,while causing an increase of glucocorticoid secretion,a large number of glucocorticoid in the body can inhibit the accumulation of immune response,resulting in animal depression,anorexia and increased symptoms such as attack and speed up the formation of gastric ulcer.4.Glycyrrhizic of exercise stress ulcer prevention and treatment a significant role,with the corresponding control group,movement,exhaustive fatigue Dosing and Dosing rats decreased gastric ulcer index.5.The study found that licorice can regulate nerve - the endocrine system disorders,stress pepsin content of rats,ChAT,CORT,NOS,such as the role of good regulation can improve gastric mucosal blood flow and ease its hypoxia-ischemia state;enhance the metabolism of free radicals and effectively inhibit stress ulcer produced.