Non-alcoholic Fatty Liver Disease Clinical Research Literature Evaluation And Demonstration Of Design,

The medical documents manifest the important results of the development of medicine and wealth.Based on fully analyzing can make better use of results and experience formerly.The development of evidence-based medicine is the methodology support of taking the better use of analysis,evaluation and use of documents resources.The good quality of the clinical research which instruct the clinical practice.The evidence-based medicine follows the scientific evidences that came from the randomized controlled trials which scientifically designed,Good multi-center,and large sample.However,the majority of Chinese medicine clinical trials which lack of the design scientifically proposal,the big sample size and the standard and unification treatment course which influenced the use of Chinese medicine and international exchanges.Therefore,it is necessary that summarized the defect of the clinical trials and solve the problem for the standardizing of the design clinical trials.Objective:1.Explore the factors that impact on the quality of clinical research.2.Investigate the standardized design of clinical trials of Chinese medicine.Methods:1.Take the Non-alcoholic fatty liver quality evaluation of clinical trials for example,searching the medical documents by the key word of Non-alcoholic fatty liver"(NAFLD) from CNKI,PUBMED,MEDLINE,SPRINGER,Cochrane Library,and so on.Excluded the non-correlated documents,and then evalued the quality of the rest of documents for three different interventions to carry out the clinical study design affect the quality of the comparison factors.2.According to clinical trial design requirements,take shuganjiangzhi fang for example to design the good quality of clinical trials.Results:Searching 5610 documents inluding both English and Chinese documents,4438 Chinese documents,1172 English documents.Bring in 95 documents finally.67 documents for Chinese medicine treatment,19 documents for Western Medicine treatment and 9 documents for cooperation of Chinese and Western medicine treatment.There are no documents ofⅠa andⅠb level of evidence,84 documents ofⅡa,4 documents ofⅡb and 7 documents ofⅢb.Conclusion:1.From the evaluation of the documents can draw the conclusion that the following aspects:the quality of the documents is poor,level of evidence of documents is low,the sample size is small in RCT,and utilize the wrong statistical methods in clinical trials.As a result,The results of the scientific value of the medical profession can hardly be recognized.2.Standard clinical trials take the important roles in improving the quality of the TCM trials.