Pharmacodynamics Kyy01 Treatment Of Depression And The Mechanism Discussed

Depression is a disease which is characterized by various manifestations of affective disorder,the symptom is diverse,such as the motion low fall,sleep and appetite obstacle,the cynical and suicide obsession,the companion that have has the plant nerve function mess.Chinese medicine practitioners believe that depression caused by that Blood barrier,organ dysfunction,and performances feelings of depression,restless mood,chest full nausea and pain,easy to cry and angry,feeling pharyngeal foreign in body sensation.According to World Health Organization statistics,the incidence of depression is about 3.1%,in developed countries is close to 6%.It will be the second largest illness in 2020.Patients with the disease has seriously affected the normal work,study and life in living,so how effectively the treatment of depression has been extensive attention.The medicine is the main method that treatment the depression.The traditional different wreath anti-suppresses the depression medicine treatment index that number narrow,and differ by sex,easy occurrence interaction for merger to use,influence the efficacy of medicine and patient obeys sex;Now the new anti-suppresses of the medicine of depression,such as the selectivity hydroxytryptamine(serotonin) take again the opposite side effect of depressant small,and likes by sex,but the price is more expensive for peopler.On this basis of the traditional theories,traditional Chinese medicine(TCM)have played more and more important part in treating depression.Classical prescriptions have showed that a satisfactory prospect on treating depression.For looking for the more safe,valid and badly reaction smaller,the cheap anti-of price suppresses the medicine of depression,more and more researcher will participation the Chinese medicine medicine realm that the taste throws to enrich toward resources.KYY01 is the drugs in this topic subjects,which is compositioned by powder of the Wuling and Extract of Hypericum.As we all know that Extract of Hypericum perforatum could treatment of depression.and Participation Wuling powder could Anti-stress.we research that the efficacy of KYY01 in treating depression and the Mechanism,and to evaluate the role of the party as well as the preliminary study of antidepressant treatment of depression its possible mechanisms.The study and results:In this study,we use four types of animal model to research that the efficacy of KYY01 in treating depression and the mechanism.the results are as follows: 1 Effects of KYY01 on Behavior despair of animalWhen mice in despair,they will not move,antidepressants could reduce the immobility time.but central stimulants and the changes in the body state will impact of this phenomenon.1.1 mouse forced swimming testIn 4 min,model mice to swim the longest fixed,KYY01 700mg/kg group of mice can effectively shorten the immobility time in forced swimming(p＜0.05).1.2 tail suspension test in miceIn 4 min,model mice immobility time in tail suspension growth,KYY01 350mg/kg group of mice can effectively shorten the immobility time in tail suspension.(p＜0.05).1.3 Weight and self-activity in miceThere was no significant effects on the motor activity in mice.Explain KYYO1 Grain have no excitement or repress the function to the central nervous system.Conclusion:These three experiments,KYY01 could treat the depression,and it can't excited about the central,Will not change the function of the state of the body.2 Effects of KYY01 on drug-induced depression modelWe use these types of animal model to research that whether the KYY01 treatment of depression caused by some neurochemical effects.2.1 Yohimbine enhanced toxicity experimentsKYY01 each dose group were more than the number of dead mice in control group,but there is not statistical difference.(p＞0.05)2.2 Model in mice by intraperitoneal injection of reserpineReserpine decreased the body temperature of mice,ptosis and can not campaign.KYY01 350g/kg group increased body temperature(p＜0.05).KYY01 700g/kg have against the trend of ptosis,KYY01 350mg/kg group can increase the movement of mice KYY01 700g/kg campaign group against the trend staticing.(p＜0.05)2.3 5-Tryptophan serotonin mice Shaking his headthe views of the Model group shaking his head is the least.KYY01 700mg/kg dose group can increase the number of such Phenomenon.(p＜0.05)Conclusion:According to The three experimental,KYY01 treatment of depressionis with these reason: Increasing the number of5-HT,NE,DA and Enhancing these role. 3.Effects of KYY01 on the chronic stress depressant model with ratsWith the control group and pseudo-operation group,the anopheles partial degrees of sugar water reduced in model rats.And model rats in the open box in the horizontal movement and vertical movement reduced.Morris water maze latency in the growth of GPS navigation,space Searching in the fourth quadrant to shorten the duration and distance,Plasma ACTH,Cort,CRH increased(p＜0.05).The neurotransmitters in the Hippocampus reduced.Positive drug group to prevent these changes(p＜0.05).The three doses of KYY01 all increased the quantity of the water with carbohydrate which was drunk by the rats.The number of sport in the open field test were increased as well.according to our findings of water maze,Shorten the Escape latent period of the fifth day and the seven day obviously,and increase the search space in the fourth quadrant of the duration and distance;490mg/kg could reduced plasma ACTH,Cort,CRH.And inprove the neurotransmitters in the Hippocampus(p＜0.05).According to our findings,KYY01 treatment of depression may be the mechanism by regulating the hormone balance to curb the excessive activation of HPA axis,and Increase monoamine neurotransmitters in brain and inhibition of their metabolism,and these effectiveness are main in 5-HT4.Effects of KYY01 on the behavior of rats with the Olfactory Bulb impairmentWith the control group and pseudo-operation group,model rats in the open box in the horizontal movement and vertical movement increased.Morris water maze latency in the growth of GPS navigation,space Search ing in the fourth quadrant to shorten the duration and distance,the 5-HT_1A in hippocampus receptors was increased.(p＜0.05).Positive drug group to prevent these changes(p＜0.05).KYY01 490mg/kg group increased the number of sport in the open field test were increased as well.according to our findings of water maze,Shorten the Escape latent period of the fifth day and the seven day obviously,and increase the search space in the fourth quadrant of the duration and distance;the three dozensof KYY01 group could reduced plasma 5-HT1A and MAO in the Hippocampus(p＜0.05).We see that KYY01 could impact 5-HT system by increasing 5-HT_1A,and maybe it is a MAOIs.Conclusion:The results showed that KYY01 could treatment of depression,and the mechanism is:regulationing the leave of ACTH and Cort,to resuma negative feedback,regulationing the hormone of the HPA axis,inhibitioning MAO and increasing the neurotransmitters in hippocampus of the brain and inhibition of their metabolism.From the combined effect of these areas,it can be in the treatment of depression.