.4 Immunohistochemistry Indicators To Predict Breast Assignment Aggressive Significance Of Paget's Disease

[Objective]EMPD is a rare skin malignancy tumor with good prognosis but some EMPDs have rapid progression.To have a better view of this rare disease and explore some specific prognostic markers,we studied the EMPD tissues by immunohistochemistry.[Materials and Method]We collected 40 cases received surgery in our institution and 43 formalin-fixed and paraffin-embedded tissues of this 40 EMPD cases were investigated on the expression of E-Cadherin,MMP-9,HER-2 and AR by means of the immunohistochemistry.[Results]The expression of E-Cadherin,MMP-9,HER-2 and AR are 47.5%,45%, 52.5%and 50%,respectively.The same figures in invasive EMPDs are 10%, 78%,67%and 80%,respectively.Among these four marks E-cadherin loss has an association with invasive EMPD significantly(P=0.003) as well as the type of EMPD(P=0.027).The progression-free survival time is much longer in the patients with HER-2(+1) than HER-2(+2) expression(P=0.0029).[Conclusion]EMPDs confined in dermis are more invasive than in epidermis. E-Cadherin is a perfect prognostic marker to predict the invasion of EMPD. The role of HER-2 and AR to predict the prognosis of EMPD remains controversy although their significant association with disease invasion.