Extend The Exposure Time To The Mouse Lung Matrix Metalloproteinase (mmp) -9 And E-cadherin Expression Research

Objective To investigate effects of prolonged delivery time modeling intensity -modulated radiatfion therapy on the expression of MMP-9 and E-cadherin in Lewis pulmonary carcinoma.Methods Lewis pulmonary carcinoma models in 40 C57BL/6 male mice were prepared and randomly divided into 4 groups equally:sham-irridiated group,con-ventional radiotherapy group(A group),two modeling IMRT groups(B1group,B2group,) with different prolonged fraction delivery time.The mice in group A,group B1 and group B2 were irradiated with 6 MV X-rays at a dose of 15Gy.All the mice were executed at 24 hours after irradiation respectively.the changes of MMP-9,E-cadherin expression in tumor tissues were examined.Results 1.Differences of the expression of MMP-9, E-cadherin between groups had statistical significance(P＜0.01 or p＜0.05),the expression of MMP-9,E-cadherin of A group was the highest.2.Differences of the expression of MMP-9,E-cadherin between groups had notable statistical significance(P＜0.01).The expression of in A group was the lowest.Conclusion Prolonged fraction dose-delivery time modeling intensity-modulated radiatrion therapy induced the expression of MMP-9 protein increased and the expression of E-cadherin decreased.