Medicine Silymarin Xiaozheng Decoction Involved In The Survival Of Primary Liver Cancer

Background:Hepatocellular carcinoma(HCC) is one of the most common maligncy in china and even the world. Cancer mortality is the second position in China and it was on the increase trend. And it is higher malignant cancer, more difficult treatment, faster development and shorter survival time. HCC has been recognized as one of the most serious malignancy hazardous to human life and health. In recent decades with the development in basic and clinical research on HCC and application of more new therapies in clinic, the survival rate has risen markedly, but it still need to improve furtherly. Furthermore, the recurrence rate of HCC remains high, even small heptocellular carcinoma, the 5-year recurrence rate was still as much as 40%~50%. Therefore, an effective therapy method to extend the survival time and survival rates of liver cancer patients need to find.Objective:To study the influencing of the survival time of hepatocellular carcinoma in patients, undergoing Transcatheter Arterial Chemoembolization (TACE) combining with Chinese traditional medicine (CTM) was used. According to this study, enlarge the methods of liver cancer therapy, and tries to find out the virtues and shortcoming of new therapy method.Methods:This study retrospectively analyzed the hepatocellular carcinoma in patients (a total of 64 patients in this group, 55men, 9 women)who underwent TACE at the Department of Tumor, Affiliated Hospitol of Chinese traditional medicine Uneversity of Beijing. And follow-up was conducted by telephone connections or the petition, collectioning the type of CTM(Pixu, Qizhi, Xue yu, Yinxu, Shire)and tumor period (Ⅰ,Ⅱa�'�Ⅱb) factors and computation the survival time. These factors were dataed and were assessed by spss13.0 software. Kaplan-Meier method was used to evaluate survival rate and median survival period.Results:1. Up to now, 16 cases were survival , 48(75%) patients were dead in 64 cases. Our data showed that the1, 2, 3 years cumulative SR in total group of heoatectomy was 79.3%, 55.9%, 21.1% and median survival time in patients with HCC was 25 months.2. The 1, 2, 3years SR in TACE combined CTM group and TACE were82.3%, 60.9%, 26.4% and 74.5%, 50.9%, 17.0% (p<0.05).3. In different tumor period′s cases with HCC, TACE combined CTM group have a more high SR and median survival time inⅠandⅡa period′s liver cancer, compared with TACE group (P<0.05),and the increase of SR and median survival time ofⅠperiod′s liver cancer was the highest one(P=0.031).4. In different type of CTM′s cases with HCC, TACE combined CTM group have a more high SR and median survival time in Pixu, Qizhi, Yinxu type of CTM′s liver cancer, compared with TACE group(P<0.05).and the increase of SR and median survival time of Qizhi type liver cancer was the highest one(P=0.034).Conclusions:1. Chinese Traditional Medicine (Yigan Xiaozheng Tang) can extend the survival time and survival rates of patients who underdoing TACE.2. Chinese Traditional Medicine (Yigan Xiaozheng Tang) can extend the survival time and survival rates ofⅠandⅡa period′s liver cancer who underdoing TACE.But has no significance forⅡb period′s liver cancer.3. Chinese Traditional Medicine(Yigan Xiaozheng Tang) can significantly improve the prognosis of patient with Pixu, Qizhi, Yinxu type of CTM′s liver cancer which underdoing TACE. But has no significance for Xueyu type of CTM's liver cancer.4. Chinese Traditional Medicine has a respectively influencing in Qizhi type liver cancer andⅠperiod′s liver cancer.