| Objective: To evaluate the difference of efficacy, side-effects, TTP and MST in advanced gastric cancer patients treats with oxaliplatin plus 5-FU or taxane plus platinum and 5-FU.Method: Retrospective review is conducted on 93 cases of chemotherapy-naive advanced gastric cancer patients treated with oxaliplatin+5FU or taxane+platinum+5-FU from July 2001 to November 2006. The statistical analysis was performed by SPSS13.0.Results: The object response rate was 45.5% for two drugs group and 56.3% for three drugs group( P=0.310). Median time to progression was 5.20 months vs. 5.50 months (P=0.361). Median survival time was 8.97 months vs. 12.00 months(P=0.119). The most frequent side-effects are nausea, vomit and hematological toxicities. The rates of gradeâ…¢-â…£neutropenia are 15.6% vs. 71.1%(P=0.008).Conclusion: Both regimens are active in advanced gastric cancer. According to the disparity of age, sex, performance status and other prognosis of patients, we choose different regiment. |
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