10 Km Treatment Of Malignant Pleural Effusion Of Mice Experimental Study And Clinical Observation

Objective: Experimental study the influence of 10 Decoction on the survival, chestand ascites, and vascular endothelial growth factor (VEGF) in chest and ascites ofhydrothorax type mice inoculated Ehrlich ascites carcinoma cell lines; Clinicalobservation 10 Decoction thoraco-abdominal cavity and cisplatin combinationchemotherapy with cisplatin alone abdomen chemotherapy efficacy and toxicitycomparative analysis; To testify the effection of 10 Decoction for malignant pleural,ascites and explore the role of its mechanism by experimental study and clinicalobservation.Method: Experimental study on mice with malignant effusions, ascites 10 Decoctionmodel, the 5-FU different drugs and doses of a treatment. Observation 10 Decoction ofmalignant pleural effusion or ascites dissipated and the survival time, ELISA mice withmalignant ascites and pleural effusion of blood VEGF content; according to the clinicalpart of the standard in 30 patients with malignant pleural effusion or malignant ascitespatients were randomly divided into treatment and control groups, no statisticallysignificant difference analysis. In the control group alone, abdomen DDPchemotherapy, the treatment group with DDP chemotherapy abdomen at the time oftreatment with 10 Decoction, After four treatment cycles, compared two groups is alarge decline, toxicity and quality of life of the difference.Results: Experiment: the vaccination strain is a large tumor model in mice usingdifferent drugs for the treatment of observation, 10 Decoction group of malignantpleural effusion or ascites reduction and survival are better than those of the controlgroup, and there is a significant difference. And 5-FU group, the Chinese MedicinesBoard survival were significantly longer; Reduction in hydrothorax and ascites,medicine, the high-dose group was better than 5-FU group and a significant differenceChinese low-dose group and the 5-FU group no significant difference. With the controlgroup, the low-dose group of Chinese medicine, Chinese medicine-dose group,Chinese high-dose serum VEGF were reduced to varying degrees, and there was asignificant difference; Chinese group and the comparison group 5-FU serum VEGF no significant difference; Chinese medicine which low dose group and the Chinesehigh-dose group showed a significant difference. Hydroperitouium right mouse VEGFstudies show Chinese low-dose group, Chinese herbal medicine and Chinese medicinedose of high dose group than the control group of mice, VEGF levels were reduced tovarying degrees, there is a significant difference; Chinese-dose group, Chinesehigh-dose group, the content of VEGF group compared with 5-FU was no significantdifference, after treatment has significantly reduced, And Chinese herbal medicinedose and high dose of Chinese medicine was no significant difference, compared withthe 5-FU group. Chinese pair of low-dose VEGF mice hydroperitouium content isnegligible. Clinical research: 10 Decoction thoraco-abdominal cavity and cisplatincombination chemotherapy in the treatment group compared with only cisplatin in thetreatment of the control group with four cycles of abdomen After chemotherapy,compared two groups of ascites, toxicity and quality of life treatment group ascitesreduction and quality of life than the control group and a significant difference Inresponse toxicity were treated group and the control group were not significantlydifferent.Conclusion: Decoction through 10 pairs of Ehrlich ascites carcinoma cell lines andhydrothorax type mice survival and chest, ascites and the decline in serum, vascularendothelial growth factor (VEGF) in an experimental study found 10 Decoctionextended survival period, reduce hydrothorax and ascites and hydrothorax and ascitesreduced vascular endothelial growth factor (VEGF) has made significant role. Chineseherbal medicine and Chinese medicine dose of high dose group in vascular endothelialgrowth factor (VEGF) with the traditional chemotherapy drug 5-FU effect of When, inprolonging survival and reducing the hydrothorax and ascites areas more than 5-FU.Clinical studies found that 10 Decoction thoraco-abdominal cavity and cisplatincombination chemotherapy with cisplatin alone, compared to chemotherapy, to bemore effective in reducing ascites patients and improve the quality of life. 10Decoction is a drinking water treatment in the name of party, as well as clinical use inmalignant pleural effusion and the treatment of malignant ascites the basic recipe. Theresults of experimental and clinical observations of 10 Decoction for malignant pleural, ascites provide preliminary evidence and information and for the efficacy of 10Decoction and lay a foundation for exploring the mechanism. At present, the TCMSyndrome disease and identified on the basis of an integrated combination of modernmedical treatment of malignant pleural effusion and malignant ascites graduallyshowing good clinical efficacy. But in the application of modern pharmacology,immunology and molecular biology theory to explain the action mechanism should befurther explored. This is the future we should work objective, we can better demonstratethe Chinese medicine bright prospects better for the majority of patients with life andhealth protection.