Buck Tongmai Kidney Damage In Spontaneously Hypertensive Rats Experiments And Mechanism Study

Hypertension nephrosclerosis (HN) refers to arteriolarnephrosclerosis caused by high blood pressure, the most of which isbenign nephridial angiosclerosis. At least, there are two methods to studyhigh blood pressure in modern medicine: one is that the atherosis lead byhypertension causes the anoxic pathological changes in nephridial tissue;the other is that HN begotten by a kidney hurt via glomerulus highpressure and high precessurese. Besides, the condensation of excellularmatrix and some special cytokines in nephridial tissue can cause thepathological changes of renal artery, renal glomerulus, and nephric tubulematrix lead by hypertension. Some studies show that high blood pressuredo harm to heart and kidney simultaneously and relatively. The routinetherapy of modern medicine can improve the indications of blood flowdynamics and ameliorate symptom partially, but it can not change theprogress of HN. Furthermore, when kidney function is harmed to someextent (Scr>3mg/dl), the application of ACEI and ARB is limited;therefore, the therapies of traditional chinese medicine (TCM) to HN arevaluable to attempt.In this report, we applied normal male wistar Kyoto (WKY) rat andspontaneously hypertensive rat (SHR) and planed to treat them with JiangYa Tong Mai Fang at the early stage, and observe the influence of theTCM therapy to the expression of indications (blood,β2-MG,24h urinealbumin, NAG, Scr and UN) of earlier phase ranodamage and therelationship of the indications and earlier phase ranodamage, in order toprovide grounds for preventing and curing HN with TCM. The WKY ratsand SHR rats in the experiments were 14 weeks old, and the rats weredivided into normal group (treated with physiological saline), TCM group(treated with Jiang Ya Tong Mai Fang), western medicine group (WM,treated with Captopril), and control group (treated with physiologicalsaline) according to theβ2-MG in 24h urine albumin and NAG. TheSHR rats were measured arteria caudilis pressure every two weeks. Whenall the experiment groups were treated for 14 weeks, i.e., the rats were 24weeks old, theβ2-MG in 24h urine albumin and NAG of the rats weresampled and examined. Compared to the WKY rats, blood pressure,β2-MG in 24h urine albumin (P<0.01) of SHR rats in each group raisedremarkably, and the arteria caudilis pressure of SHR rats raised obviously,too. When compared with TCM group , WM group and control to groups,we found that the situation of blood pressure of WM group is better thanthat of TCM group, but theβ2-MG in 24h urine albumin and NAG ofTCM group is better than that of WM group and control group. Theresults of the experiments exhibited that the difference of arteria caudilispressure between SHR rats and WKY rats in each group is not significant. The arteria caudilis pressure of TCM group is significantly lower than thatof control group, but higher than that of WM group; theβ2-MG in 24hurine albumin and NAG of TCM group is significantly lower than that ofWM group and control group. Based all the data in the experiments, wecan draw the following conclusions: high blood pressure does great harmto kidney. Compound Jiang Ya Tong Mai Fang can regulate the bloodpressure of SHR rats, but the curing effect of which is not better than thatof Captopril. The protective effects on kidney damaged by HN ofcompound Jiang Ya Tong Mai Fang is prior to the single western medicine.