Citrus Aurantium The Peony Scattered Demolition Party, Adjust The Intestinal Hypersensitivity

The Irritable Bowel Syndrome (IBS) is one of the most frequent diseases in the digestive system. It belongs to chronic bowel functional disorder and is characterized by abdominal pain or discomfort, as well as the change of bowel habit. The incidence of IBS ascends constantly along with living rhythm speedind up. IBS isn't a dreadful disease which intimidates the human being's health, but as it recurrent attacks and is a chronic disease, the work and life of patients are affected in different degree. Therefore, it is a serious problem we have to solve as soon as possible that heighten the treating level.Although Western medicine has carried out the study on IBS constantly, there isn't yet any a kind of medicine or monotherapy fully good for IBS now. Chinese medicine has had a complete recognition on the treatment of IBS and built up affluent clinical experience. IBS is equivalent to bowel depression in the book of technical terms of Chinese medical disease pattern and methods of treatment. It belongs to abdominal pain, or diarrhea, or constipation of Chinese medicine, too. Unripe bitter orange and Peony Powder came from the famous Chinese medical monograph of Synopsis of the Golden Chamber which wrote by Zhang zhongjing in Han dynasty. It is composed by two herbs, Unripe bitter orange and Red peony. It is characterized by abdominal pain and abdominal distention, and can treat the stagnation of qi and blood in the bowel. From the symptoms and causes, the Pattern of Unripe bitter orange and Peony Powder is very close to IBS. From the habit of using herbs of Zhang zhongjing, Unripe bitter orange and Red peony is the frequently used herbs of treating abdominal pain and abdominal distention. Although the application and research of Unripe bitter orange and Peony Powder are scarce now, the research of Unripe bitter orange and Red peony are very deeply. The study has discovered that Unripe bitter orange decocotion can strengthen the rhythm of gastrointestinal smooth muscle contraction, and the paeonin, the key component of peony, can relax smooth muscle cells and lengthen colonic systolic time. Therefore, there are the theoretical and experimental bases of Unripe bitter orange and Peony Powder treating IBS.Based on the above, to investigate the possible role of Unripe bitter orange and Peony Powder in the treatment of IBS, we carried out the study on Unripe bitter orange and Peony Powder modulating the bowel hypersensibility by divided design. The article is composed of 3 parts.In the first part, we reviewed the modern and Chinese medical researches on the Irritable Bowel Syndrome, including its incidence, pathogenesis, diagnosis and treatment.In the second part, we discussed the feature and application of Unripe bitter orange and Peony Powder, the theoretical basis of the treatment of IBS from the liver and spleen, the application of harmonizing the liver and spleen in tne book of Treatise on Cold-Attack. Unripe bitter orange and Peony Powder has the features of harmonizing the liver and spleen, qi and blood. Harmonizing the liver and spleen is one of commonly methods of treatment used by Zhang zhongjing, and reflects the thingking of Zhang zhongjing about harmonizing therapy.In the last part, we observed the modulatory effects of Unripe bitter orange and Peony Powder on the bowel sensibility, MCs and SP of ileum and colon mucosa in the bowel hypersensibility rats. The results show that every observed thing of the bowel hypersensibility rats was markedly increased compared to that of the controls. Red peony could decrease the number of the MCs in the ileum and colon mucosa of the bowel hypersensibility rats, but not for SP. Unripe bitter orange could decrease the terminals of SP in the ileum and colon mucosa of the bowel hypersensibility rats, but not for MCs. Unripe bitter orange and Peony Powder was more effective in modulating the bowel sensibility and MCs and SP of ileum and colon mucosa than Unripe bitter orange and Red peony.From the results we can find that modulation of MCs and SP of ileum and colon mucosa may be involved in Unripe bitter orange and Peony Powder treating the Irritable Bowel Syndrome.