Medicine Morning Sickness Treatment Of Vomiting Of Pregnancy 30 Cases Of Clinical Observation And Mechanism

Objective:To study the clinical therapeutic effect of YunTuFang combining intravenous fluid infusion therapy on the patients suffering Vomiting During Pregnancy(VDP) and explore the mechanism .Methods :90 early-pregnant women in Department of gynecology of Hospital No.1 Wuhan during May 2004 to Oct. 2005 were collected,60 cases of VDP in which were devided into two groups randomly as therapy group(n=30) and control group(n=30). The normal early-pregnant were compared with the forenamed groups as the normal group.Therapy group was treated with the YunTuFang of invigorating qi,nourishing yin,harmonizing stomach and calming fetus in the base of intravenous fluid infusion treatment,while the control one was given only the general treatment. YunTuFang Prescription (YP,mainlycomposed of Pesudostellariae heterophy lla,Scute llaria baicalensis Georgi,Aucklandia lappa Decne, Atractylodes macro Cephala Koidz, Ophiopogon japonicus ,Dendrobium , Stems of Perrila frutescens Britt, Suscuta chinen sis Lam,Taxillus chinensis,Prunus mume, Bamboo bark, Glycyrrhiza). The decoction was to be taken in small doses at short interval .The general treatment was privided as following :5%GS ,NS,1000₁500ml and Ringer's 2000 ml,added vitamin C 2g, vita min B₆ 0.1g ,ATP(Adenosine Triphosphate)40mg, inosine injection 0.4,and sodium bicarbonate injection 125ml,and (or)the 10% injection KCL 10ml acording to the results of serum electrolytes. The concentration of MOT was detected with ELISA and which of P-HCG was mearured with electrochemiluminescence (ECL) when the treatment had been begun for 6 days.Results :1. The recovery rate and the total effective rate were76.7% and 96.7% in therapy group and 56.7% and 90% in control group. By verification,the difference of the recovery rate between the two groups was distinct statistical significance (p < 0.05),but the difference of the total effective rate wasn't obvious.2.The concentrations of P-HCG in the therapy, control and normal group were 136230 ± 15120 mlU/ml , 155816 ± 14624 mlU/ml , 129213 ± 10528 mlU/ml respectively before treatment. The serum P-HCG levels in treatment group were lower than the control one, the diference between them was significant(P < 0.05),and which of the control one was obviously higher than the normal one ,the diference was significant(P < 0.05).While the difference between the treatment and the control group was not significant (P > 0.05).3.The concentrations of MOT in therapy group and control one were 67.15± 15.94 and 70.28±13.56 respectively before treatment,which were not significantly diferrent and obviously lower than the level of the normal one (145.35 ± 30.12 ). The MOT levels of the VDP had increased significantly compared with those before the treatment,but which of treatment group(151.50±54.84) were significantly higher than the control one(103.28±38.31). The difference of the MOT level between the treatment and the nomal group was not significant (P > 0.05), while the difference between the control and normal group was obvious(P < 0.05).Conclusion :1. The concentration of P-HCG showed significant in relation to VDP.2. MOT showed significant correlation with VDP which maybe the mechanism...