Protection Effect And Mechanism Of Injury. Qingnaoxuanqiao Dripping Pills On Cerebral Ischemia

Cerebrovascular, well known for its high incidence, high death rate, high relapse rate and high mutilation rate, is one of the most serious threat to the health of human being, which brought serious burden to the patients, families and society. According to the epidemiological study, the death rate of cerebrovascular disease has become the first of all the diseases since 1997. The incidence of ischemic cerebrovascular disease is higher than hemorrhagic cerebrovascular disease. So deeper research about the mechanism of ischemic cerebrovascular disease and the main points of the pathological changes has extremely important significance in modern medical.Qingnaoxuanqiao Compound Prescription is an experienced Compound Prescription in clinical by Academician Wang Yongyan, which consists Fructus Gardeniae, Radix notoginseng and Borneolum syntheticum. It follows the principle of traditional Chinese Medicine and has a good effect in the treatment of acute issue and early convalescence period of ischemic brain apoplexy. The phytochemistry laboratory got this effective fraction using macrous absorptive resins to assemble the active component. It is a prospective drug in curing the ischemic cerebrovascular disease which has less toxicity, less side effects and small dosage.In the dissertation, the effects of Qing Nao Xuan Qiao Dropping pill(QNXQD) were investigated in vivo and in vitro respectively on tissue, cellular and molecular levels depending on the current researches on mechanism of ischemic cerebrovascular disease. The methods in the research of protective effect and its possible mechanism of QNXQD included methods in physiology, biochemistry and immunohistochemistry.1 Rationality of QNXQD's preparation 1.1 Contrast of Protective effects of QNXQD before and after passing the macrous absorptive resins on the Middle cerebral artery thrombus (MCAT) model induced by FeCl3By using Middle cerebral artery thrombus (MCAT) model induced by FeCl3, detecting the neurological symptoms and infarct size, we compared the Protective effect of QNXQD before and after passing the macrous absorptive resins on the...