Angongniuhuang Pill Of Ancient And Modern Literature

AnGong NiuHuang Wan came from the Treatise on Differentiation and Treatment of Febrile Diseases which was written by Wu Ju-tong in Qing Dynasty. Due to its primary function, such as heat-clearing, detoxicating, phlegm-eliminating and resuscitation, this formula was always used in the syndrome of evil heat defecting pericardium. There are 12 kinds of herbs in the pill, including Niuhuang, Xijiao, Yujin, Shexiang, Zhenzhu, Zhizi, Huanglian, Huangqin, Zhusha, Xionghuang, Bingpian, Jinbo, et al. The formula was also one of the three most effective formulas for warm disease, and a representative formula for resuscitation by drugs with cold or cool property. The widely used dosage form of this formula was pill and powder. And both of them were used for emergency treatment. From the becoming, this formula was put high emphasis on by many doctors or specialists. Thus, there were many papers about the evaluation, research, or application of it. It was applied as a key drug for febrile convulsion, stoke or coma in clinical.In this paper, the relative papers about Angong Niuhuang Wan in the last 20 years'journals were reviewed firstly.The main body of this paper was based on the discussion of the Treatise on Differentiation and Treatment of Febrile Diseases. By tracing back to the source, going over all the correlated original statement, analyzing the consisted principle, a summary about its indicatio and contraindication was obtained. Namely the core cure disease was coma caused by evil heat defecting pericardium. The comment and application of the later annotators and contemporary famous experts were also analyzed, and the focal point of modern clinical use was investigated. Come to a conclusion that precise consideration is needed in clinical, and then reasonably use it in indicatio despite those toxic herbs included and strictly prohibited in contraindication.At last, the method of learning and application of ancient formulas was discussed. It was emphasized to trace something to its source and think highly of original literature.