Lipoprotein-associated Phospholipase A2 And Coronary Heart Disease,

Objective To evaluate the feasibility and safety of radiofrequency catheter ablation for eradication of symptomatic ventricular ectopic beat。Methods This study included 49 patients(M/F17/32,mean age 41.6±10.5 years;Right ventricular outflow tract oringin in 46 patients and left ventricular outflow tract oringin in 3 patients with severely symptomatic frequent ventricular ectopic beats .The site of origin was determined by activation mapping for the earliest endocardial activation, and/or by pacemapping for the exact QRS match between pacing and ectopic beat.Results Radiofrequency catheter ablation successed in 87.6%(43/49) patients with a mean frequency of ventricular ectopic beats of 157/24hours after the ablation.No complications encountered. During a mean follow-up period of 5-29 months,the patient with successful ablation were not given any antiarrhythmic drugs and were symptom-free in most of them(83.7%). Recurrence occurred in 2 patients in the 43 successful cases, and there were no late complications.Conclusion ablation is an effective and safe treatment for frequent ventricular ectopic beats. It may therefore be a reasonable alternative for the treatment of severely symptomatic, drug-resistant or intolerable ventricular ectopic activities in patients without significant structural heart disease.