The Cilnidipine Solid Dispersion Preparation And Rats In The Small Intestinal Absorption Kinetics

Cilnidipine is inhibitation of Ca²⁺. It can not only prevent the type L of Ca²⁺ which can get into blood smooth mucle , but also can prevent the Ca²⁺ passage ways of type L. It is the main point of blood smooth mucle to diastole the outside prevenment and the coronary artery. And the most influence of preventing the Ca²⁺ passage ways of type N is the end of the contamination nerves. Deduce the consistency of Ercafenan which is found in blood in order to coronary the blood vessel. So, it has the double actions of preventing. But it can not be made into normal tablet because of its undissolving.In the passage the low co-melt is made up with Cilnidipin and different supplementary metials, and is made into solid dispersion when it is iced. It can be celelect by the prescription that PVPk30 equals one fifth is the best proportion to be propared. The best dissolvtion of the body outside is percent 89. 6. The picture analyze that in the low dissolvous mixture, the peak of original crystal. In the passage the experiment of themedical dynamics absorbing in small intestine of mouse. Point out that Cilnidipine can make a good absore in all intestine. The absorb of each ten centimeter is that auodenum is 0. 149, the empty of the intestine is 0. 194, the ileum is 0. 129, the crown is 0.168, the different absorb in each intestine is samilla . It is said that there is not any obvious section of absorbing in small intestine. In the different condition of PH, if the PH is raising, the absorbing can also raising so suspect that the pessive of the importment absording of Cilnidipine in the intestine of the mouse passive spread.It will improve living exploit of Cilnidpin through solid dispersion of Cilnidpine is preparation. It will be a good new form ofdrug of developing foreground.