C-erbb-2, The Expression Of Egfr And Nm23-h1 In Bladder Cancer And Its Clinical Significance

Objective To study the expression of c-erbB-2, EGFR and nm23-H1 and its clinical significance in Human Bladder cancer. Methods By means of immunohistochemical technique S-P procedure , we study the expression of c-erbB-2, EGFR and nm23-H1 in 69 cases of human bladder cancer and 12 cases of normal bladder mucosa .Results The positive expression rates of C-erbB-2,EGFR and nm23-H1 are 44.90%, 56.52% and 60.87% in bladder cancer, and are respectively 0.00% ,0.00% and 100% in normal bladder mucosa , their expression rates show distinct meaning between normal bladder mucosa and bladder cancer(p<0. 01). With the increasing of pathological grade and clinical stage of bladder cancer, the positive expression rates of C-erbB-2 and EGFR increased, however, the positive expression rate of nm23-H1 decreased . Conclusions The abnormal expression of C-erbB-2, EGFR and nm23-H1 plays an important part in the genesis and development of human bladder cancer.