Guishao Headache Particle Pharmacy And Stability Studies

Migraine, a kind of common headache, is a sort of vascular headache, which occurs from time to time with headaches in one side or both sides of the head, and is often accompanied with dizziness, nausea, vomiting and photophobia when it comes. At present, since migraine's incidence is growing and it is easy to occur repeatedly, so far there are few western medications which are effective in treating migraine yet, Chinese Medicine accordingly is drawing much attention with its own advantages.From the theory of Chinese Medicine, the basic pathology for the headache of migraine is the obstructed blood, regardless of the cause of migraine being excessive wind-evil, phlegm, dampness or weakness. Because wind-evil and stasis are the main and common cause of migraine, the basic method mainly composed of expelling wind-evil by enriching and promoting blood has extensive adaptation. When we apply it in the clinic, we can enhance or reduce its use according to the different causes.GuiShao Toutong granule is an effective medicine according to the clinic experience for many years, which consists of 9 herbs, namely radix Angelicae Sinensis(Dang Gui). radix of Paeoniae Alba(Bai Shao), radix Rehmanniae rehmannia(Sheng Di), radix Angelicae Dahuricae(Bai Zhi) , radix seu radix Nptopterydii(Qiang Huo), radix Platycodi(Jie Geng), caulis Piperis Futokadsurae(Hai Feng Teng), herba Asari(Xi Xin), radix glycyrrhizae(Gan Cao). It has the function of expelling wind-evil by enriching and promoting blood, opening the collateral channels and relieving pain, and is put into use of treating blood stasis, blood efficiency and head dizzy and headache caused by wind-evil.Guided according to Chinese Medicine Theory, in the term of "New TCM Medicine Guide", we carry out the research about preparation technology, quality standard and stability, meanwhile, we also pay attention to the moisture, temperature and sunshine about the stability of Ferulic AcidoAbout the research of preparation technology, we carry out the experiment to proceed technology optimization so that we can finally determine the optimal extracting technology and the making method according to the fixed technology.In the quality standard research, we determine the method of TCM for radix of Paeoniae Alba, radix Angelicae Dahuricae, radix Platycodi, radix glycyrrhizae in the finished product. Then, we also have the scope ofFerulic Acidin the material and preparation.After one-year stability experiment under natural conditions, headache pill is in conformation with regulations, which means the preparation is basically stable with the present package.In the Ferulic Acid's stability experiment, we foresee the term of efficacy of radix Angelicae Sinensis, the extractor of radix Angelicae Sinensis, and the Toutong granule under the closed-door circumstance. And we also come to three conclusions: the temperature's effect to the stability of Ferulic Acid is related to the existing status ofFerulic Acid; Ferulic Acidis unstable in water solution; sunshine doesnot obviously effect the contentFerulic Acid.