Pill On Rats With Experimental Chronic Renal Failure, Erectile Dysfunction And Mechanism Study

Objective: To creat the sprague-dauley(SD) rat model of Erectile Dysfunction in Chronic Renal Failure ,to observe erectile function in a rat model of chronic renal failure, and explore the mechanisms which chronic renal failure can lead to erectile dysfunction ,and the therapeutic effect of 'Jin Gui Shen Qi Wan' on erectile function.Methods: chronic renal failure was induced by adult male Sprague-Dawley rats, which were subjected to an excisional 5/6 nephrectomy. Injected with apomorphine, penile erections were observed and noted on the 2th week ,8th week and 12th week from the 14th day of 5/6 nephrectomy and experimental models of ED with CRF were selected .Two weeks later ,'Jin Gui Shen Qi Wan' suspension was perfused into their stomachs . After 30 days , to evaluate the erectile function by the injection with apomorphine, then the concentration of testosterone serum creatinine and blood uria nitrogen were examined; The microstructure of testes and penile were observed under optical microscope with BI2000 computer configuration image analysis system.Results: The concentration of testosterone decreased significantly and the significant pathological changes in rat model of Erectile Dysfunction in Chronic Renal Failure: The decrease on number of smooth muscle in corpus cavernosum penis number and caliber of seminiferous tubule in testis number of cell of Leydig in testis. Simultaneity, the concentrateion of serum creatinine and blood uria nitrogen increased significantly, and the function of penile erection was affected seriously by CRF. After post-treatment of 'Jin Gui Shen Qi Wan, all those marker had some improving tendency , compared with the modle group rats : The microstructure oftestes and penile was changed better than that of the modle group rats , testis coefficient was increased, the concentration of testosterone were changed normally , penile erectile function was improved significantly .Conclusions: We had gained the rat model of Erectile Dysfunction in Chronic Renal Failure by 5/6 nephrectomy and injection with apomorphine, and injection with apomorphine could evaluate their penile erectile function. The function of penile erection the erectile tissue in corpus cavernosum penis the microstructure of testes and the synthesis of testosterone were affected seriously by CRF, and the decreasing of the concentration of testosterone and the erectile tissue in corpus cavernosum penis may be one of the most important mechanisms. 'Jin Gui Shen Qi Wan' can improve the penile erectile function of rat model of Erectile Dysfunction in Chronic Renal Failure. The mechanisms may be much related to improvement in the microstructure of testis and penis renal function the coefficient of testis and penis serum testosterone.